US2024082125A1PendingUtilityA1

Use of a short chain fatty acid as antidandruff agent

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Assignee: UNIV NANYANG TECHPriority: Dec 21, 2020Filed: Dec 20, 2021Published: Mar 14, 2024
Est. expiryDec 21, 2040(~14.4 yrs left)· nominal 20-yr term from priority
Inventors:Tarun ChopraViduthalai Rasheedkhan ReginaScott Rice
A61K 8/36A61Q 5/006A61Q 17/005A61Q 19/00A61K 8/37A61K 8/99A61P 17/08C12P 7/40C12P 7/52C12P 7/62A61K 2800/10A61K 2800/805
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Claims

Abstract

The present invention concerns the cosmetic field, and especially cosmetic uses of at least one short chain fatty acid chosen from propionic acid, butyric acid, valeric acid, non-metallic salts thereof, esters thereof and mixtures thereof, or a conditioned culture medium obtained from at least one microorganism which is able to produce such short chain fatty acid(s), as antidandruff agent, for preventing and/or treating desquamative disorders of the skin associated with the excessive proliferation of yeasts of the Malassezia genus on the skin and for maintaining and/or restoring at a normal level, the ecoflora of the skin and especially by preventing excessive colonization of the skin by Malassezia genus and/or by mediating growth of Cutibacterium acnes.

Claims

exact text as granted — not AI-modified
1 - 6 . (canceled) 
     
     
         7 . A cosmetic process intended for preventing and/or treating desquamative disorders of the skin associated with the proliferation of yeasts of the  Malassezia  genus, comprising the application, to the hair and/or skin, of a cosmetic composition comprising an effective amount of i) at least one short chain fatty acid chosen from propionic acid, butyric acid, valeric acid, non-metallic salts thereof, esters thereof and mixtures thereof, or ii) a conditioned culture medium obtained from at least one microorganism which is able to produce one or more short chain fatty acid(s), the said medium comprising at least one short chain fatty acid chosen from propionic acid, butyric acid, valeric acid, non-metallic salts thereof, esters thereof and mixtures thereof. 
     
     
         8 . A cosmetic process intended for maintaining and/or restoring at a normal level, the ecoflora of the skin, comprising the application, to the hair and/or skin, of a cosmetic composition comprising an effective amount of i) at least one short chain fatty acid chosen from propionic acid, butyric acid, valeric acid, non-metallic salts thereof, esters thereof and mixtures thereof, or ii) a conditioned culture medium obtained from at least one microorganism which is able to produce one or more short chain fatty acid(s), the said medium comprising at least one short chain fatty acid chosen from propionic acid, butyric acid, valeric acid, non-metallic salts thereof, esters thereof and mixtures thereof. 
     
     
         9 . The cosmetic process according to  claim 7 , wherein the short chain fatty acid or the conditioned culture medium is present in an amount representing from 0.01% to 5% by weight relative to the total weight of the composition. 
     
     
         10 . The cosmetic process according to  claim 7 , wherein said cosmetic composition is in the form of a shampoo, a cream, a mousse, a paste, a gel, an emulsion, a lotion or a stick. 
     
     
         11 . The cosmetic process according to  claim 8 , wherein the short chain fatty acid or the conditioned culture medium is present in an amount representing from 0.01% to 5% by weight relative to the total weight of the composition. 
     
     
         12 . The cosmetic process according to  claim 8  wherein said cosmetic composition is in the form of a shampoo, a cream, a mousse, a paste, a gel, an emulsion, a lotion or a stick. 
     
     
         13 . The cosmetic process according to  claim 7 , wherein said desquamative disorder of the skin is dandruff and/or seborrheic dermatitis. 
     
     
         14 . The cosmetic process according to  claim 8 , wherein said method prevents excessive colonization of the skin by the yeasts of the  Malassezia  genus and/or mediates growth of  Cutibacterium acnes.    
     
     
         15 . The cosmetic process according to  claim 7 , wherein the short chain fatty acid is chosen from sodium propionate, sodium butyrate, sodium valerate, and mixtures thereof. 
     
     
         16 . The cosmetic process according to  claim 7 , wherein the short chain fatty acid is obtained from at least one microorganism of the species  Cutibacterium acnes.    
     
     
         17 . The cosmetic process according to  claim 7 , wherein the short chain fatty acid is obtained from at least one microorganism of the strain  Cutibacterium acnes  ATCC 6919. 
     
     
         18 . The cosmetic process according to  claim 7 , wherein the conditioned culture medium is obtained by the process comprising the following steps:
 a. culturing at least one microorganism which is able to produce one or more short chain fatty acid(s);   b. separating the culture supernatant from the biomass;   c. recovering the culture supernatant; and   d. optionally stabilizing the culture supernatant.   
     
     
         19 . The cosmetic process according to  claim 8 , wherein the short chain fatty acid is chosen from sodium propionate, sodium butyrate, sodium valerate, and mixtures thereof. 
     
     
         20 . The cosmetic process according to  claim 8 , wherein the short chain fatty acid is obtained from at least one microorganism of the species  Cutibacterium acnes.    
     
     
         21 . The cosmetic process according to  claim 8 , wherein the short chain fatty acid is obtained from at least one microorganism of the strain  Cutibacterium acnes  ATCC 6919. 
     
     
         22 . The cosmetic process according to  claim 8 , wherein the said conditioned culture medium is obtained by the process comprising the following steps:
 a. culturing at least one microorganism which is able to produce one or more short chain fatty acid(s);   b. separating the culture supernatant from the biomass;   c. recovering the culture supernatant; and   d. optionally stabilizing the culture supernatant.   
     
     
         23 . The cosmetic process according to  claim 22 , wherein in step a. the microorganism is of the species  Cutibacterium acnes ; the separating in step b. is by centrifugation; and the stabilizing in step d. is by filtration and/or autoclaving. 
     
     
         24 . The cosmetic process according to  claim 23 , wherein in step a. the microorganism is  Cutibacterium acnes  ATCC 6919. 
     
     
         25 . The cosmetic process according to  claim 18 , wherein in step a. the microorganism is of the species  Cutibacterium acnes ; the separating in step b. is by centrifugation; and the stabilizing in step d. is by filtration and/or autoclaving. 
     
     
         26 . The cosmetic process according to  claim 25 , wherein in step a. the microorganism is  Cutibacterium acnes  ATCC 6919.

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