US2024074989A1PendingUtilityA1

Actinic keratosis treatment

Assignee: COEGIN PHARMA ABPriority: Dec 31, 2020Filed: Dec 30, 2021Published: Mar 7, 2024
Est. expiryDec 31, 2040(~14.4 yrs left)· nominal 20-yr term from priority
A61K 31/11A61P 17/00A61K 31/121A61K 31/095A61P 35/00A61P 17/12
49
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Claims

Abstract

A compound of formula (I) R—S—CH 2 —CO—CF 3 (I) wherein R is a C 10-24 unsaturated hydrocarbon group comprising at least 4 non-conjugated double bonds; or a salt thereof; for use in the treatment of squamous cell carcinoma or actinic keratosis.

Claims

exact text as granted — not AI-modified
1 - 8 . (canceled) 
     
     
         9 . A method of treating actinic keratosis or squamous cell carcinoma comprising administering to an animal, an effective amount of a compound of formula (I):
   R—S—CH 2 —CO—CF 3    (I)
   wherein R is a C 10-24  unsaturated hydrocarbon group comprising at least 4 non-conjugated double bonds; or a salt thereof.   
     
     
         10 . (canceled) 
     
     
         11 . The method of  claim 9 , wherein the animal is a mammal. 
     
     
         12 . The method of  claim 11 , wherein the mammal is a human. 
     
     
         13 . The method of  claim 9 , wherein said hydrocarbon group R has 5 to 7 double bonds. 
     
     
         14 . The method of  claim 9 , wherein in said hydrocarbon group R, no double bond is conjugated with the carbonyl group. 
     
     
         15 . The method of  claim 9 , wherein in said hydrocarbon group R all double bonds are in the cis configuration or wherein in said hydrocarbon group all double bonds are in the cis configuration except the double bond nearest the carbonyl. 
     
     
         16 . The method of  claim 9 , wherein the R group comprises 17 to 19 carbon atoms. 
     
     
         17 . The method of  claim 9 , where the compound of formula (I) is 
       
         
           
           
               
               
           
         
       
     
     
         18 . The method of  claim 9 , wherein the compound is administered orally or topically.

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