Methods and systems for non-contact construction of an internal structure

Abstract

The present disclosure includes system, methods, and kits relating to creating a second structure with a plurality of first structures at a target site inside or adjacent to a host object. The methods include the step of generating a field that non-invasively penetrates into the host object. The methods further include the step of positioning a first portion of the plurality of first structures at the target site using a force corresponding to the field. Additionally, the methods include the step of linking the first portion of the plurality of first structures with one another and/or the host object at the target site to form the second structure.

We claim: 
     
         1 . A method for utilizing a plurality of first structures containing a material at a target site inside or adjacent to a host object, comprising:
 a) using a first external source to generate a first field that non-invasively penetrates into the host object,
 wherein the first field is generated with a first pattern; 
   b) using the first field to directly position a first portion of the plurality of first structures at the target site based on the first pattern;   c) optionally using a second external source to generate a second field that non-invasively penetrates into the host object,
 wherein the second field is generated with a second pattern; 
   d) releasing the material from the plurality of first structures,
 wherein the releasing is initiated by the first field or the second field, and 
 wherein the releasing is based on at least one of the first pattern or the second pattern; and 
   e) at least one of:
 forming, based on interactions between the materials released from the plurality of first structures, a second structure comprising the released material inside or adjacent to the host object, or 
 removing, based on interactions between the materials released from the plurality of first structures, a third structure comprising the released material inside or adjacent to the host object and at least a portion of the host object. 
   
     
     
         2 . The method of  claim 1 , wherein using a first external source to generate a first field further comprises:
 using a plurality of first external sources to generate the first pattern of the first field.   
     
     
         3 . The method of  claim 2 , wherein the first pattern of the first field comprises at least one of a plane, cylinder, sphere, Bessel, gratings, bottle, donut, grid, net, or trap. 
     
     
         4 . The method of  claim 2 , wherein the first pattern of the first field comprises a standing wave. 
     
     
         5 . The method of  claim 4 , wherein the target site is located at one of a standing wave node or a standing wave antinode. 
     
     
         6 . The method of  claim 1 , wherein optionally using a second external source to generate a second field further comprises:
 using a plurality of second external sources to generate the second pattern of the second field.   
     
     
         7 . The method of  claim 6 , wherein the second pattern of the second field comprises at least one of a plane, cylinder, sphere, Bessel, gratings, bottle, donut, grid, net, or trap. 
     
     
         8 . The method of  claim 6 , wherein the second pattern of the second field comprises a standing wave. 
     
     
         9 . The method of  claim 8 , wherein the target site is located at one of a standing wave node or a standing wave antinode. 
     
     
         10 . The method according to  claim 1 , wherein the releasing of step d) thereby forms the second structure from the material inside or adjacent to the host object, and
 wherein the interactions between the released materials are caused by at least one of a chemical bond, a magnetic force, an acoustic force, heat, or an electrostatic force.   
     
     
         11 . The method according to  claim 1 , wherein the releasing of step d) thereby removes the third structure from inside or adjacent to the host object based on the interactions between the released materials. 
     
     
         12 . The method according to  claim 1 , wherein the release of the material causes a reaction of polymerization, chemical cross-linking, or activation of a cascade in the host object. 
     
     
         13 . The method according to  claim 1 , further comprising imaging the target site to determine a desired position of the first portion of the plurality of first structures, prior to step a). 
     
     
         14 . The method according to  claim 10 , wherein the forming the second structure thereby inhibits a blood flow inside or adjacent to the host object via the second structure. 
     
     
         15 . The method according to  claim 11 , wherein the removing of the third structure thereby enhances a blood flow inside or adjacent to the host object. 
     
     
         16 . The method according to  claim 1 , wherein the first field is an acoustic field. 
     
     
         17 . The method according to  claim 1 , wherein the host object is an object within a human body. 
     
     
         18 . The method according to  claim 1 , wherein the plurality of first structures comprises hemostatic bubbles, thrombolytic bubbles, acoustomotive bubbles, or a combination thereof. 
     
     
         19 . The method according to  claim 10 , wherein the second structure: i) applies a mechanical force on a vessel wall to maintain patency of a lumen; ii) has a different size and/or shape from the plurality of first structures; iii) blocks blood flow; iv) includes an intra-cavity implant; v) creates at least one blood clot; vi) is configured to lyse a blood clot; or vii) any combination thereof.