Omega-3 fatty acid and vitamin d levels to identify and attenuate cognitive aging in individuals

Abstract

A method for identifying pre-disposition to cognitive decline in a subject, the method comprising determining levels of: (a) omega-3 fatty acids, and vitamin D or a metabolite thereof; (b) omega-3 fatty acids, and homocysteine; (c) vitamin D or a metabolite thereof, and homocysteine; or (d) omega-3 fatty acids, vitamin D or a metabolite thereof, and homocysteine, independently in one or more samples obtained from the subject.

1 - 18 . (canceled) 
     
     
         19 . A method for reducing or preventing cognitive decline in an elderly subject in need thereof, the method comprising administering 0.13 mg/day to 130 mg/day of a Vitamin B6 to the elderly subject. 
     
     
         20 . The method of  claim 19 , wherein the elderly subject is an elderly human subject. 
     
     
         21 . The method of  claim 19  comprising orally administering the Vitamin B6 to the elderly subject. 
     
     
         22 . The method of  claim 19 , comprising administering to the elderly subject a nitric oxide releasing compound simultaneously with the Vitamin B6. 
     
     
         23 . The method of  claim 22 , wherein the nitric oxide releasing compound comprises citrulline. 
     
     
         24 . The method of  claim 23 , wherein the citrulline is administered in an amount of between 0.5 g to 10.0 g per day. 
     
     
         25 . The method of  claim 19 , wherein 13 mg/day to 100 mg/day of the Vitamin B6 is administered to the elderly subject. 
     
     
         26 . The method of  claim 19 , wherein the method further comprises administering Vitamin B9 and/or Vitamin B12 with the Vitamin B6 to the elderly subject. 
     
     
         27 . The method of  claim 26 , wherein the Vitamin B9 is administered to the elderly subject in an amount between 0.004 mg/day to 2.0 mg/day. 
     
     
         28 . The method of  claim 26 , wherein the Vitamin B12 is administered to the elderly subject in an amount between 0.002 mg/day to 0.4 mg/day.