US2024041849A1PendingUtilityA1

Compounds for the treatment of neurological or mitochondrial diseases

Assignee: MUSC FOUND FOR RES DEVPriority: Jul 29, 2018Filed: Sep 29, 2023Published: Feb 8, 2024
Est. expiryJul 29, 2038(~12 yrs left)· nominal 20-yr term from priority
A61K 31/4406A61P 25/08A61K 31/136A61K 31/18C07C 225/20C07C 2602/10C07D 213/36C07C 311/08C07C 243/34C07C 229/10A61K 31/137A61K 31/122C07C 50/32A61K 31/135A61P 25/00A61P 25/16A61P 25/28A61P 25/18C07D 213/16
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Claims

Abstract

Compounds and methods are provided for the treatment of neurological or mitochondrial diseases, including epilepsy. In some embodiments, the compounds are substituted 1,4-naphthoquinones.

Claims

exact text as granted — not AI-modified
1 - 54 . (canceled) 
     
     
         55 . A compound of the formula: 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt thereof. 
       
     
     
         56 . The compound of  claim 55  further defined as: 
       
         
           
           
               
               
           
         
       
     
     
         57 . A pharmaceutical composition of  claim 55  comprising:
 (A) a compound of the formula: 
 
       
         
           
           
               
               
           
         
         
           or a pharmaceutically acceptable salt thereof; and 
         
         (B) an excipient. 
       
     
     
         58 . The pharmaceutical composition of  claim 57 , wherein the pharmaceutical composition is formulated for oral, sublingual, intranasal, intravenous, subcutaneous, parenteral, inhalation, or aerosol delivery. 
     
     
         59 . The pharmaceutical composition of  claim 57 , wherein the pharmaceutical composition is formulated as a unit dose.

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