Benefits of supplementation with n-acetylcysteine and glycine to improve glutathione levels

Abstract

Compositions and methods are related to utilizing glycine and N-acetylcysteine for a variety of medical conditions related to reduced levels of glycine, N-acetylcysteine, and/or glutathione, for example, muscle loss such as sarcopenia, HIV infection and other infections, organ damage such as those from diabetes and insulin resistance and diabetic nephropathy, cardiac function and failure such as preventing or improving heart failure, fatty liver, cancer prevention, and other conditions.

The invention is claimed as follows: 
     
         1 : A method of achieving an effect in an individual, the method comprising administering an effective amount of a composition comprising glycine and N-acetylcysteine to the individual, the effect selected from the group consisting of:
 improvement of muscle performance and recovery,   increased longevity,   improvement of cognitive function,   improvement of memory,   provement of skeletal muscle loss,   improvement of insulin sensitivity,   increased fat oxidation,   reduced body weight,   lower excess fat content in the liver,   lower cholesterol level,   lower triglyceride level,   improving cardiac contractile function,   improving maternal and fetal health in gestational diabetes, and   improving exercise capacity and physical function.   
     
     
         2 : The method of  claim 1 , wherein the glycine and the N-acetylcysteine are provided to the individual in the same composition. 
     
     
         3 : The method of  claim 1 , wherein the glycine and the N-acetylcysteine are provided to the individual in different compositions. 
     
     
         4 : The method of  claim 1 , wherein the glycine and the N-acetylcysteine are administered orally to the individual. 
     
     
         5 : A method of preventing or delaying onset of a condition or state of in an individual, the method comprising administering an effective amount of a composition comprising glycine and N-acetylcysteine to the individual, the condition or state selected from the group consisting of:
 dyslipidemia,   fatty liver disease,   non-alcoholic fatty liver disease,   myopathy,   sarcopenia,   HIV infection,   cachexia,   deleterious effects of weightlessness,   heart failure,   cancer,   obesity,   neurodegenerative disease,   Nephropathy,   neuropathy prevention for acetaminophen toxicity,   non-alcoholic steatohepatitis,   tinnitus,   dizziness,   alcohol hangover,   hearing impairment,   Alzheimer's,   Parkinson's Disease,   osteoporosis,   hypertension,   atherosclerosis/coronary artery disease,   myocardial damage after stress, such as from burns or trauma;   cystic fibrosis,   inflammation,   traumatic brain injury (including concussions),   improve recovery from general trauma and surgery,   diabetes prevention, and   treatment or prevention of pre-diabetes/metabolic syndrome.   
     
     
         6 : The method of  claim 5 , wherein the glycine and the N-acetylcysteine are provided to the individual in the same composition. 
     
     
         7 : The method of  claim 5 , wherein the glycine and the N-acetylcysteine are provided to the individual in different compositions. 
     
     
         8 : The method of  claim 5 , wherein the glycine and the N-acetylcysteine are administered orally to the individual.