Delivery devices for delivering and methods of delivering compositions

Abstract

Disclosed embodiments relate to devices and related methods for delivering a composition to a subject. In some embodiments, a device may include a catheter coupled to a handle. The handle may include proximal and distal handle portions that are moveable relative to one another to selectively expose a needle at a distal end of the catheter. The proximal handle portion may include a container coupling and a grip extending proximally from the container coupling.

1 . A device for delivering a composition to a subject, comprising:
 a catheter comprising:
 an outer sheath tube, 
 an inner tube, and 
 a hollow needle coupled to a distal end of the inner tube; and 
   a handle comprising:
 a proximal handle portion including a container coupling and a grip extending proximally relative to the container coupling, 
 a distal handle portion coupled to the outer sheath tube, and 
 a channel extending through the handle and fluidly coupled with the container coupling, wherein the inner tube extends at least partially along a length of the channel and is in fluid communication with the container coupling, 
   wherein the proximal and distal handle portions are moveable relative to one another between a first position in which the needle is retracted within the outer sheath tube and a second position in which the needle extends from the outer sheath tube.   
     
     
         2 . The device of  claim 1 , wherein the container coupling is configured to couple to a syringe. 
     
     
         3 . The device of  claim 2 , wherein the syringe extends substantially parallel to the grip when coupled to the container coupling. 
     
     
         4 . The device of  claim 2 , wherein the container coupling comprises a luer fitting. 
     
     
         5 . The device of  claim 1 , further comprising a finger loop positioned adjacent a proximal end of the grip. 
     
     
         6 . The device of  claim 1 , further comprising one or more hypotubes disposed within the channel of the handle. 
     
     
         7 . The device of  claim 6 , wherein the inner tube extends through the one or more hypotubes. 
     
     
         8 . The device of  claim 6 , wherein a first hypotube of the one or more hypotubes is attached to the inner tube. 
     
     
         9 . The device of  claim 8 , wherein a second hypotube of the one or more hypotubes is attached to the handle, and the first hypotube is moveable through the second hypotube. 
     
     
         10 . The device of  claim 1 , wherein a length of the catheter is between about 300 mm and about 1000 mm. 
     
     
         11 . The device of  claim 1 , further comprising an endoscope having a working channel, wherein at least a portion of the catheter is received within the working channel. 
     
     
         12 . The device of  claim 1 , wherein the proximal and distal handle portions are axially slideable relative to one another to move between the first and second positions. 
     
     
         13 . The device of  claim 12 , wherein the handle comprises a keyed arrangement constructed and arranged to prevent rotation of the proximal handle portion relative to the distal handle portion. 
     
     
         14 . The device of  claim 13 , wherein the keyed arrangement comprises a rail formed on the proximal handle portion received in a groove formed in the distal handle portion. 
     
     
         15 . The device of  claim 1 , wherein the channel is tapered such that an inner diameter of the channel decreases from a proximal to distal direction. 
     
     
         16 . (canceled) 
     
     
         17 . The device of  claim 16 , wherein the first taper angle is greater than the second taper angle. 
     
     
         18 . The device of  claim 1 , wherein the inner tube has a wall thickness of 50 μm to 600 μm. 
     
     
         19 . The device of  claim 1 , wherein the inner tube includes a reinforcement feature comprising a microfilament attached to a wall of the inner tube. 
     
     
         20 . The device of  claim 1 , further comprising a sleeve surrounding a portion of the outer sheath tube, the sleeve being freely slidable over the outer sheath tube. 
     
     
         21 . A method of administering a composition, comprising:
 gripping a handle of a delivery device with a first hand, wherein the delivery device includes a catheter extending distally from the handle, and at least a portion of the catheter is received in a working channel of an endoscope;   gripping a handle of the endoscope with the first hand while gripping the handle of the delivery device; and   depressing a plunger of a syringe with a first finger of the first hand to deliver a compound through the catheter, wherein the syringe is coupled to the handle of the delivery device.   
     
     
         22 - 29 . (canceled)