Methods For The Effective Treatment Of Metastatic Cancer

Abstract

The present invention relates to methods for the treatment of metastatic cancer. Methods of treating metastatic cancer by administration of a set of drugs overcome multiple mechanisms of melphalan resistance and hypersensitize cancer cells to melphalan are described. The methods involve the administration of drug(s) that induce oxidative stress in cancer cells, in conjunction with melphalan on a defined schedule.

1 .- 39 . (canceled) 
     
     
         40 . A combination for therapy for treating metastatic cancer or refractory metastatic cancer in a subject, comprising:
 a therapeutically effective dose of bizelesin or a pharmaceutically acceptable salt thereof, wherein the therapeutically effective dose of bizelesin is approximately 1 μg/m 2  to approximately 20 μg/m 2 ,   bone marrow stem cells, and   an MDR-1 pgp pump inhibitor or a pharmaceutically acceptable salt thereof, wherein the MDR-1 pgp pump inhibitor is erythromycin in an amount of approximately 3 mg/kg to approximately 5 mg/kg every 6 hours with a maximum of 4 grams/day.