Intraocular pressure sensing material, devices, and uses thereof

Abstract

Described herein are eye implants that can include a pressure-responsive material that can be capable of changing color in response to pressure exerted on it. Also described here are methods of implanting and using the eye implants described herein to monitor intraocular pressure in a subject. The pressure-responsive material can be used to diagnose and monitor human or animal subjects.

We claim: 
     
         1 . An intraocular implant comprising:
 a pressure-responsive material, the pressure-responsive material comprising chromogenic photonic crystals, wherein the chromogenic photonic crystals change conformation resulting in a change of color of the pressure-responsive material in response to an amount of pressure exerted on the shape-memory chromogenic photonic crystals and wherein the chromogenic photonic crystal comprise smart shape memory polymers (SMPs), wherein the implant is an intraocular lens.   
     
     
         2 . The intraocular implant of  claim 1 , wherein the pressure-responsive material is a first color at a normal physiologic intraocular pressure of about 10 to about 20 mm Hg, wherein the first color ranges from about 500 nm to 550 nm corresponding to a green color. 
     
     
         3 . The intraocular implant of  claim 2 , wherein the pressure-responsive material is a second color at an elevated intraocular pressure of greater than about 20 mm Hg, wherein the second color ranges from about 400 nm to 450 nm corresponding to a blue color. 
     
     
         4 . The intraocular implant of  claim 3 , wherein the pressure-responsive material is a third color at a reduced intraocular pressure of less than about 10 mm Hg, wherein the third color ranges from about 600 nm to 650 nm corresponding to a red color. 
     
     
         5 . An intraocular implant comprising:
 a pressure-responsive material, the pressure-responsive material comprising chromogenic photonic crystals, wherein the chromogenic photonic crystals change conformation resulting in a change of color of the pressure-responsive material in response to an amount of pressure exerted on the shape-memory chromogenic photonic crystals and wherein the chromogenic photonic crystal comprise smart shape memory polymers (SMPs), wherein the implant is a glaucoma drainage device.   
     
     
         6 . The intraocular implant of  claim 5 , wherein the pressure responsive material is coated on a surface of a drainage tube of the glaucoma drainage device. 
     
     
         7 . The intraocular implant of  claim 6 , wherein the surface is an outer surface of the drainage tube. 
     
     
         8 . The intraocular implant of  claim 6 , wherein the surface is an inner surface of the drainage tube. 
     
     
         9 . An intraocular implant comprising:
 a pressure-responsive material, the pressure-responsive material comprising chromogenic photonic crystals, wherein the chromogenic photonic crystals change conformation resulting in a change of color of the pressure-responsive material in response to an amount of pressure exerted on the shape-memory chromogenic photonic crystals and wherein the chromogenic photonic crystal comprise smart shape memory polymers (SMPs), wherein the implant comprises one or more layers of the pressure-responsive material embedded in all or part of a surface of the implant or component thereof.   
     
     
         10 . An intraocular implant comprising:
 a pressure-responsive material, the pressure-responsive material comprising chromogenic photonic crystals, wherein the chromogenic photonic crystals change conformation resulting in a change of color of the pressure-responsive material in response to an amount of pressure exerted on the shape-memory chromogenic photonic crystals and wherein the chromogenic photonic crystal comprise smart shape memory polymers (SMPs), wherein the implant comprises one or more layers of the pressure-responsive material coated on all or part of a surface of the implant or component thereof.   
     
     
         11 . The intraocular implant of  claim 10 , wherein each of the one or more layers is about 0.5 mm to about 3 mm thick. 
     
     
         12 . An intraocular implant comprising:
 a pressure-responsive material, the pressure-responsive material comprising chromogenic photonic crystals, wherein the chromogenic photonic crystals change conformation resulting in a change of color of the pressure-responsive material in response to an amount of pressure exerted on the shape-memory chromogenic photonic crystals and wherein the chromogenic photonic crystal comprise smart shape memory polymers (SMPs), wherein the pressure-responsive material is integrated with a component of the implant.   
     
     
         13 . An intraocular implant comprising:
 a pressure-responsive material, the pressure-responsive material comprising chromogenic photonic crystals, wherein the chromogenic photonic crystals change conformation resulting in a change of color of the pressure-responsive material in response to an amount of pressure exerted on the shape-memory chromogenic photonic crystals and wherein the chromogenic photonic crystal comprise smart shape memory polymers (SMPs), wherein the pressure-responsive material comprises a hydrogel.