System and Method for Background Removal in Spectrometry System

Abstract

An analysis system includes a separation system that provides compounds to a sample cell of a spectrometric system. The system analyzes spectral information from the spectrometric system by optimizing retention windows for the compounds and identifies quantities of the compounds by comparing spectral information within and outside the respective retention windows.

1 - 32 . (canceled) 
     
     
         33 . An analysis system, comprising:
 a separator for separating a sample into its compounds;   a spectrometric system for gathering sample spectra of the compounds eluting from the separator; and   a computer system that analyzes the compounds from the sample spectra by defining multiple, separate quant regions in reference spectra for a compound of interest and analyzing the sample by comparing sample spectra to the multiple regions in the reference spectra.   
     
     
         34 . A system as claimed in  claim 33 , wherein the computer system provides correction vectors for the quant regions. 
     
     
         35 . A system as claimed in  claim 34 , wherein the correction vectors correct for baseline drift. 
     
     
         36 . A system as claimed in  claim 34 , wherein the computer system provides different correction vectors for each of the quant regions. 
     
     
         37 . A system as claimed in  claim 33 , wherein the computer system generates a graphical user interface displaying spectra and allowing the user to graphically define at least one of the multiple quant regions on the spectra. 
     
     
         38 . A system as claimed in  claim 33 , wherein the computer system analyzes the compounds based further on background spectra of the sample that were taken before and/or after the compound of interest eluted; and determines quantities of the compounds of interest in the sample. 
     
     
         39 . A system as claimed in  claim 38 , wherein the background spectra include at least two background spectra collected before the compound of interest eluted, and includes at least two background spectra collected after the compound of interest eluted. 
     
     
         40 . A system as claimed in  claim 33 , wherein the reference spectra are obtained from spectral libraries. 
     
     
         41 . A system as claimed in  claim 33 , wherein regression matrices for compounds of interest include sample spectra taken when the compounds of interested eluted, reference spectra for the compounds of interest and multiple background spectra of the sample that were taken before and/or after the compounds of interest eluted.