Nasogastric device and method

Abstract

A nasogastic device and method is provided, including a first flexible tube having a distal end configured to be threaded through the nose of a patient, down the esophagus and into the stomach for enteral feeding, a second flexible tube disposed adjacent to the first tube having a distal end proximate to the distal end of the first flexible tube, the distal end of the second tube configured to terminate inside the esophagus for delivery of liquids to the esophagus or for sampling of the local environment, an inflatable balloon configured around the first and second flexible tubes, the inflatable balloon disposed proximal to the distal end of the first and second flexible tubes, a third flexible tube in fluid communication with the balloon configured to inflate the inflatable balloon; and a fourth flexible tube having a distal end portion communicating with an exterior portion of the inflatable balloon, the fourth tube configured to transport suspensions or solutions of materials, such as therapeutic molecules into a space exterior to the inflatable balloon; and an elastomeric sleeve surround the inflatable balloon and around the fourth flexible tube which is used to control delivery of therapeutic suspensions of solutions of materials to the exterior of the device to the adjacent esophagheal tissue.

1 . A nasogastric device, comprising:
 a first flexible tube having a distal end configured to be threaded through the nose of a patient, down the esophagus and into the stomach;   a second flexible tube disposed adjacent to the first tube having a distal end proximate to the distal end of said first flexible tube, the distal end of said second tube configured to terminate inside the esophagus;   an inflatable balloon configured around said first and second flexible tubes, the inflatable balloon disposed proximal to the distal end of the first and second flexible tubes;   a third flexible tube in fluid communication with said balloon configured to inflate said inflatable balloon; and   a fourth flexible tube having a distal end portion communicating with an exterior portion of said inflatable balloon, the fourth tube configured to transport suspensions or solutions of materials, such as therapeutic molecules into a space exterior to said inflatable balloon.   
     
     
         2 . A nasogastric device in accordance with  claim 1 , wherein at least a portion of the distal end of said first flexible tube includes perforations configured to allow material injected into said tube to exit freely into the stomach. 
     
     
         3 . A nasogastric device in accordance with  claim 2 , wherein said perforations have a length of between 1 and 8 millimeters. 
     
     
         4 . A nasogastric device in accordance with  claim 1 , wherein at least the last 5 centimeters of the distal end of said first flexible tube includes perforations. 
     
     
         5 . A nasogastric device in accordance with  claim 1 , wherein the distal end of said second flexible tube extends between 1 and 10 centimeters below the distal end of said first inflatable balloon. 
     
     
         6 . A nasogastric device in accordance with  claim 5 , wherein at least a portion of said distal end includes perforations that have a length of between 1 and 3 millimeters. 
     
     
         7 . A nasogastric device in accordance with  claim 1 , wherein said inflatable balloon has an initial radius of between about 5 millimeters and 2 centimeters. 
     
     
         8 . A nasogastric device in accordance with  claim 1 , wherein said inflatable balloon has an initial length of between about 0.5 and 30 centimeters. 
     
     
         9 . A nasogastric device in accordance with  claim 1 , further comprising an elastomeric sleeve at least partially surrounding said inflatable balloon, elastomeric sleeve in fluid communication with said fourth tube, the elastomeric sleeve including perforations configured to allow release of said therapeutic molecules there through. 
     
     
         10 . A nasogastric device in accordance with  claim 2 , wherein said perforations are configured as semicircular patterns. 
     
     
         11 . A nasogastric device in accordance with  claim 10 , wherein said perforations are configured having lengths between about 0.5 micrometers and 25 millimeters. 
     
     
         12 . A nasogastric device in accordance with  claim 9 , wherein elastomeric sleeve is configured to closely surround at least a portion of the inflatable balloon such that inflation of the inflatable balloon pushes therapeutic molecules contained within elastomeric sleeve through the perforations of elastomeric sleeve. 
     
     
         13 . A nasogastric device in accordance with  claim 9 , further comprising at least one radiopaque marker provided near a distal portion of an element of said nasogastric device. 
     
     
         14 . A nasogastric device in accordance with  claim 1 , further comprising ports configured at the proximal ends of each of said four tubes. 
     
     
         15 . A method of treating an esophageal stricture, comprising:
 providing a nasogastric device, including:   a first flexible tube having a distal end configured to be threaded through the nose of a patient, down the esophagus and into the stomach;
 a second flexible tube disposed adjacent to the first tube having a distal end proximate to the distal end of said first flexible tube, the distal end of said second tube configured to terminate inside the esophagus; 
 an inflatable balloon configured around said first and second flexible tubes, the inflatable balloon disposed proximal to the distal end of the first and second flexible tubes; 
 a third flexible tube in fluid communication with said balloon configured to inflate said inflatable balloon; and 
 a fourth flexible tube having a distal end portion communicating with an exterior portion of said inflatable balloon, the fourth tube configured to transport suspensions or solutions of materials, such as therapeutic molecules into a space exterior to first inflatable balloon; and 
   positioning said nasogastric device utilizing visualized radiopaque markers at an esophageal stricture;   injecting a therapeutic vehicle through said fourth flexible tube; and   inflating the inflatable balloon against said esophageal stricture and simultaneously delivering said therapeutic vehicle to esophageal tissue adjacent the inflatable balloon.   
     
     
         16 . A method in accordance with  claim 15 , further comprising additionally providing enteral feeding via said first flexible tube. 
     
     
         17 . A method in accordance with  claim 16 , wherein said first flexible tube includes perforations on at least a distal portion thereof to facilitate enteral feeding. 
     
     
         18 . A method in accordance with  claim 16 , wherein said perforations have a length of between 1 and 8 millimeters. 
     
     
         19 . A method in accordance with  claim 15 , wherein an elastomeric sleeve at least partially surrounds said inflatable balloon, and wherein said inflating of said inflatable balloon forces said therapeutic vehicle through perforations of elastomeric sleeve to esophageal tissue adjacent to the device. 
     
     
         20 . A method in accordance with  claim 15 , wherein the distal end of said second flexible tube extends between 1 and 10 centimeters below the distal end of said inflatable balloon.