Topical compositions comprising pea proteins and polyphenols

Abstract

The object of the invention is topical compositions comprising pea proteins and polyphenols and the use thereof for the treatment of local or generalised disorders caused by increased permeation of the natural epithelial barriers. Said disorders may be of bacterial, viral, inflammatory, allergic and/or fungal origin, or endogenous or idiopathic.

1 . Method of treating localised disorders of bacterial, viral, inflammatory, allergic and/or fungal, endogenous, or idiopathic origin caused by permeation of the natural epithelial barriers, and disorders transferred from the epithelia to other systems in a subject in need thereof, said method comprising:
 administering a pharmaceutically effective amount of topical the compositions comprising pea protein and polyphenols of the hydroxycinnamic and hydroxybenzoic acid families selected from ferulic acid, isoferulic acid, gallic acid and rosmarinic acid wherein the weight ratio of polyphenol to pea protein is from 0.4:1 to 1:10, in admixture with a suitable carrier to said subject.   
     
     
         2 . The method according to  claim 1 , wherein said localized disorders comprise atopic dermatitis, rosacea, psoriasis, contact dermatitis, dermatitis caused by exposure to sunlight, radiotherapy or chemotherapy, cutaneous candidiasis, fungal infections, vaginal candidiasis, polybacterial vaginitis, fungal and bacterial infections of the skin and mucous membranes, and infections caused by protozoa. 
     
     
         3 . The method according to  claim 1 , wherein the polyphenol is ferulic acid. 
     
     
         4 . The method according to  claim 1 , wherein the weight ratio of polyphenol to pea protein ranges from 1:1 to 1:6. 
     
     
         5 . The method according to  claim 1 , wherein the weight ratio of polyphenol to pea protein is 1:1. 
     
     
         6 . The method according to  claim 1 , wherein the compositions are in the form of ointments, lotions, creams, solutions, suspensions, gels, mouthwashes, medicated plasters or gauzes, powders, or pessaries. 
     
     
         7 . The method according to  claim 1 , wherein the compositions further comprise moisturising, emollient, humectant, preservative, antioxidant, or pH-regulating additives. 
     
     
         8 . The method according to  claim 7 , wherein the additives are selected from lectin, lactic acid, sericin, poloxamers, carrageenan and arabinoxylan. 
     
     
         9 . The method according to  claim 8 , wherein the additives are selected from lectin, poloxamers, carrageenan and arabinoxylan, each in concentrations by weight ranging from 0.1 to 2.5%.