Methods for determining and achieving therapeutically effective doses of anti-cd47 agents in treatment of cancer

Abstract

Methods are provided for treating a subject with an anti-CD47 agent.

1 - 21 . (canceled) 
     
     
         22 . A pharmaceutical aqueous formulation comprising an effective dose of Hu5F9-G4 antibody;
 and pharmaceutically acceptable excipients comprising 10 mM sodium Acetate, 5% (w/v) sorbitol, 0.01% (w/v) polysorbate 20, pH 5.0.   
     
     
         23 . The formulation of  claim 22 , wherein the effective dose of Hu5F9-G4 antibody comprises from 10 to 40 mg/kg. 
     
     
         24 . The formulation of  claim 22 , comprising 200 mg of Hu5F9-G4 antibody. 
     
     
         25 . The formulation of  claim 22  in a liquid dosage form for IV infusion. 
     
     
         26 . The formulation of  claim 22 , in single use 10 ml. vials. 
     
     
         27 . An article of manufacture comprising a unit dose of a formulation according to  claim 22 . 
     
     
         28 . A method of treating an individual in need thereof by administering an effective dose of an antibody formulation according to  claim 22 .