Compositions comprising a serotonergic tryptamine compound

Abstract

Disclosed herein are compositions comprising a serotonergic tryptamine compound, combinations thereof, and methods of using them for treating and preventing a variety of human conditions. In one embodiment, disclosed herein are new compositions and methods which comprise a therapeutically effective amount of a first purified psilocybin derivative and a therapeutically effective amount of a second compound. The second compound is selected from the group consisting of a second purified psilocybin derivative, a purified terpene, a serotonergic drug, an adrenergic drug, a dopaminergic drug, a purified erinacine, and a purified hericenone.

What is claimed is: 
     
         1 . A psilocybin derivative of formula A: 
       
         
           
           
               
               
           
         
       
       wherein:
 one of R 1 , R 2 , and R 3  is an electron pair or a hydrogen and the others of R 1 , R 2 , and R 3  are each independently selected from an alkyl, an alkenyl, or an alkynyl; 
 R 5  is a carbonate ester; and 
 R 4 , R 6 , R 7 , R 8 , R 9 , and R 10  are each independently selected from an electron pair, a hydrogen, an alkyl, an alkenyl, an alkynyl, a phenyl, a halide, a hydroxyl, a carbonyl, an aldehyde, a haloformyl, a carbonate ester, a carboxylate, a carboxyl, an ester, a hydroperoxy, a peroxy, an ether, a hemiacetal, a hemiketal, an acetal, a ketal, an orthoester, a methylenedioxy, an orthocarbonate ester, carboxamide, an amine, an imine, an amide, an azide, an azo, a cyanate, a nitrate, a nitrile, an isonitrile, a nitrosooxy, a nitro, a pyridyl, a thiol, a sulfide, sulfinyl, a sulfonyl, a thiocyanate, a carbonothioyl, or a phosphate. 
 
     
     
         2 . The psilocybin derivative of formula A, wherein one of R 1 , R 2 , and R 3  is an electron pair and the others of R 1 , R 2 , and R 3  are both an alkyl. 
     
     
         3 . The psilocybin derivative of formula A, wherein one of R 1 , R 2 , and R 3  is a hydrogen and the others of R 1 , R 2 , and R 3  are both an alkyl. 
     
     
         4 . A composition comprising:
 a first purified psilocybin derivative, wherein the purified psilocybin derivative is a psilocybin derivative of  claim 1 ; and   a second compound selected from the group consisting of a second purified psilocybin derivative, a purified terpene, a serotonergic drug, an adrenergic drug, a dopaminergic drug, a purified erinacine, and a purified hericenone.   
     
     
         5 . A composition comprising:
 a first purified psilocybin derivative, wherein the purified psilocybin derivative is a psilocybin derivative of  claim 2 ; and   a second compound selected from the group consisting of a second purified psilocybin derivative, a purified terpene, a serotonergic drug, an adrenergic drug, a dopaminergic drug, a purified erinacine, and a purified hericenone.   
     
     
         6 . A composition comprising:
 a first purified psilocybin derivative, wherein the purified psilocybin derivative is a psilocybin derivative of  claim 3 ; and   a second compound selected from the group consisting of a second purified psilocybin derivative, a purified terpene, a serotonergic drug, an adrenergic drug, a dopaminergic drug, a purified erinacine, and a purified hericenone.