US2023398225A1PendingUtilityA1
Pd-l1/sting conjugates and methods of use
Est. expiryNov 21, 2038(~12.3 yrs left)· nominal 20-yr term from priority
A61K 31/506C07D 471/04A61K 31/4439A61K 47/65A61K 31/437A61P 35/00A61K 31/4184A61K 47/60A61K 31/519A61K 47/55A61K 47/545C07D 519/00
71
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Claims
Abstract
The present application relates to conjugates of STING agonists and small molecule modulators of the PD-1/PD-L1 protein/protein interaction, as well as methods of treating cancer using the conjugates.
Claims
exact text as granted — not AI-modified1 . A compound of Formula (I):
P-L-S (I)
or a pharmaceutically acceptable salt thereof, wherein P is a ligand that binds to cell surface PD-L1 protein and induces PD-L1 internalization, L is a linking group, and S is a moiety that agonizes STING.
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