Method for preparing amino acid mixed solid and apparatus for preparing amino acid mixed solid

Abstract

The present disclosure relates to a method for preparing an amino acid mixed solid, including a first step of preparing an amino acid mixed solution containing an amino acid; a second step of stirring the amino acid mixed solution to form a thin film, and drying and pulverizing the formed thin film to prepare wet granules; and a third step of drying the wet granules to prepare an amino acid mixed solid in a granular formulation, wherein, the second step is conducted for drying the amino acid mixed solution so that a solid concentration in the wet granules is within a granulation concentration range.

1 . A method for preparing an amino acid mixed solid, the method comprising:
 a first step of preparing an amino acid mixed solution containing an amino acid;   a second step of stirring the amino acid mixed solution to form a thin film, and drying and pulverizing the formed thin film to prepare wet granules; and   a third step of drying the wet granules to prepare an amino acid mixed solid in a granular formulation,   wherein, the second step is conducted for drying the amino acid mixed solution so that a solid concentration in the wet granules is within a granulation concentration range.   
     
     
         2 . The method for preparing an amino acid mixed solid of  claim 1 ,
 further comprising a step of preparing granules using a mixed-type granulator after the second step has been performed and before the third step is performed,   wherein at least a portion of the wet granules prepared in the second step is used as a seed for preparing the granules in the mixed-type granulator.   
     
     
         3 . The method for preparing an amino acid mixed solid of  claim 1 ,
 wherein the second step is conducted for controlling the granulation concentration range depending on the kind of amino acids.   
     
     
         4 . The method for preparing an amino acid mixed solid of  claim 1 ,
 wherein the amino acid includes at least one selected from the group consisting of L-threonine, L-tryptophan, L-valine, L-isoleucine, and L-leucine.   
     
     
         5 . The method for preparing an amino acid mixed solid of  claim 1 ,
 wherein the first step includes preparing the amino acid mixed solution by a fermentation method using at least one selected from a microorganism of the genus  Brevibacterium, Corynebacterium, Escherichia, Serratia, Erwinia, Enterobacteria, Streptomyces,  or  Pseudomonas  or an artificial mutant thereof.   
     
     
         6 . The method for preparing an amino acid mixed solid of  claim 1 ,
 wherein a linear speed to stir the amino acid mixed solution in the second step is 4 m/s to 17 m/s.   
     
     
         7 . The method for preparing an amino acid mixed solid of  claim 1 ,
 wherein the second step is performed at 0.05 atm to 0.6 atm.   
     
     
         8 . The method for preparing an amino acid mixed solid of  claim 1 ,
 wherein the third step includes a drying process using a fluidized-bed granulator/dryer.   
     
     
         9 . The method for preparing an amino acid mixed solid of  claim 1 ,
 further comprising a process of concentrating the amino acid mixed solution after the first step has been performed and before the second step is performed.   
     
     
         10 . An apparatus for preparing an amino acid mixed solid, the apparatus comprising:
 a fermenter for producing an amino acid mixed solution through a fermentation process;   a thin film drying apparatus for drying and pulverizing the amino acid mixed solution supplied from the fermenter to prepare wet granules; and   a granule drying apparatus for drying the wet granules to prepare an amino acid mixed solid in a granular formulation,   wherein the thin film drying apparatus includes:   a stirring unit of the thin film drying apparatus for stirring the amino acid mixed solution to form a thin film provided from the amino acid mixed solution on a thin film drying apparatus inner wall; and   a heating unit for heating the thin film drying apparatus inner wall to dry the thin film.   
     
     
         11 . The apparatus for preparing an amino acid mixed solid of  claim 10 ,
 wherein the stirring unit of thin film drying apparatus and the thin film drying apparatus inner wall are isolated by a distance of 5 mm to 15 mm.   
     
     
         12 . The apparatus for preparing an amino acid mixed solid of  claim 10 ,
 wherein the amino acid mixed solution is dried in the thin film drying apparatus so that a solid concentration in the wet granules is within a granulation concentration range, and   the granulation concentration range is controlled depending on the kind of amino acids.   
     
     
         13 . The apparatus for preparing an amino acid mixed solid of  claim 10 ,
 further comprising a mixed-type granulator for preparing granules using at least a portion of the wet granules prepared in the thin film drying apparatus as a seed.