Devices and methods for the treatment of vascular abnormalities

Abstract

Described herein is a medical device for treating a target site. The medical device includes a proximal end including a disc and a distal end including a lobe. The disc and lobe are connected by a connecting member. The disc includes a proximal surface, a distal surface, and a central surface extending between and connecting the proximal surface and distal surface, wherein the central surface separates the proximal surface from the distal surface by a predetermined depth distance.

What is claimed is: 
     
         1 . An occluder for occluding a left atrial appendage (“LAA”), the occluder comprising:
 a lobe positioned at a distal end of the occluder and configured to be positioned within a body of the LAA; 
 a disc positioned at a proximal end of the occluder and configured to abut tissue at an opening of the LAA; and 
 a connecting segment that connects the disc to the lobe and spaces apart the disc from the lobe; 
 wherein the occluder has a collapsed condition when received within a delivery catheter and a pre-set expanded condition in the absence of applied forces; 
 wherein the disc includes a proximal surface defining a first diameter, and a distal surface defining a second diameter, the distal surface separated from the proximal surface by a depth such that an enclosed cavity is defined between the proximal surface and the distal surface, the depth being between 1 mm and 10 mm and the first diameter being about equal to the second diameter in the expanded configuration of the occluder. 
 
     
     
         2 . The occluder of  claim 1 , wherein the disc includes a side surface extending between the proximal surface and the distal surface 
     
     
         3 . The occluder of  claim 2 , wherein the side surface includes a radius of curvature between 2 mm and 10 mm. 
     
     
         4 . The occluder of  claim 1 , wherein the occluder is formed of nitinol. 
     
     
         5 . The occluder of  claim 4 , wherein the disc is formed as a heat-set fabric. 
     
     
         6 . The occluder of  claim 4 , wherein the disc includes a frame. 
     
     
         7 . The occluder of  claim 6 , wherein the disc includes a fabric coupled to the frame. 
     
     
         8 . The occluder of  claim 2 , wherein the side surface extends linearly between the proximal surface and the distal surface. 
     
     
         9 . A system for occluding a left atrial appendage (“LAA”), the system comprising:
 an occluder comprising:
 a lobe positioned at a distal end of the occluder and configured to be positioned within a body of the LAA, a disc positioned at a proximal end of the occluder and configured to abut tissue at an opening of the LAA, and a connecting segment that connects the disc to the lobe and spaces apart the disc from the lobe; and 
 
 a delivery device comprising:
 a delivery catheter; 
 a delivery cable within the delivery catheter and translatable with respect to the delivery catheter; and 
 a coupling member configured to couple the occluder to the delivery cable for facilitating at least one deployment of the occluder at the LAA, 
 
 wherein the occluder has a collapsed condition when received within the delivery catheter and a pre-set expanded condition in the absence of applied forces; 
 wherein the disc includes a proximal surface defining a first diameter, and a distal surface defining a second diameter, the distal surface separated from the proximal surface by a depth such that an enclosed cavity is defined between the proximal surface and the distal surface, the depth being between 1 mm and 10 mm and the first diameter being about equal to the second diameter in the expanded configuration of the occluder. 
 
     
     
         10 . The system of  claim 9 , wherein the disc includes a side surface extending between the proximal surface and the distal surface 
     
     
         11 . The system of  claim 10 , wherein the side surface includes a radius of curvature between 2 mm and 10 mm. 
     
     
         12 . The system of  claim 9 , wherein the occluder is formed of nitinol. 
     
     
         13 . The system of  claim 12 , wherein the disc is formed as a heat-set fabric. 
     
     
         14 . The system of  claim 12 , wherein the disc includes a frame. 
     
     
         15 . The system of  claim 14 , wherein the disc includes a fabric coupled to the frame. 
     
     
         16 . The system of  claim 10 , wherein the side surface extends linearly between the proximal surface and the distal surface. 
     
     
         17 . A method for occluding a left atrial appendage (“LAA”), the method comprising:
 providing an occluder comprising a lobe positioned at a distal end of the occluder, a disc positioned at a proximal end of the occluder, and a connecting segment that connects the disc to the lobe and spaces apart the disc from the lobe; 
 advancing the occluder to the LAA using a delivery system including a catheter and a delivery cable, wherein the occluder is in a collapsed condition within the catheter during the advancing; 
 deploying the occluder from the catheter so that the lobe self-expands into a body of the LAA and so that the disc self-expands to abut tissue at an opening of the LAA to occlude blood flow; and 
 de-coupling the occluder from the delivery cable, 
 wherein the disc includes a proximal surface defining a first diameter, and a distal surface defining a second diameter, the distal surface separated from the proximal surface by a depth such that an enclosed cavity is defined between the proximal surface and the distal surface, the depth being between 1 mm and 10 mm and the first diameter being about equal to the second diameter in an expanded configuration of the occluder. 
 
     
     
         18 . The method of  claim 17 , wherein after deploying the occluder from the catheter, a radial center portion of the distal surface of the disc is positioned within the body of the LAA and a peripheral edge of the distal surface of the disc abuts tissue at the opening of the LAA. 
     
     
         19 . The method of  claim 17 , wherein after deploying the occluder from the catheter, tension from the connecting segment tends to pull the distal surface of the disc away from the proximal surface of the disc. 
     
     
         20 . The method of  claim 17 , wherein the occluder is formed of nitinol, the disc includes a frame and a fabric coupled to the frame.