Glycoprotein Hormone Long-Acting Superagonists

Abstract

This invention provides long-acting, superactive analogs of glycoprotein hormones demonstrating enhanced bioactivity both in vitro and in vivo as compared to wild type counterparts. The analogs are particularly useful for treating subjects showing low receptor expression or poor receptor responsiveness, and for the treatment of any condition associated with glycoprotein hormone activity.

1 .- 19 . (canceled) 
     
     
         20 . A modified equine alpha subunit polypeptide comprising SEQ ID NO: 4. 
     
     
         21 . A modified glycoprotein hormone whose polypeptide sequences consist of the alpha subunit polypeptide of  claim 20  and a wild-type beta subunit of equine chorionic gonadotropin (CG). 
     
     
         22 . A modified equine alpha subunit comprising SEQ ID NO: 9. 
     
     
         23 . A method of stimulating a CG receptor in an equine, comprising administering the modified glycoprotein hormone of  claim 20  to said equine. 
     
     
         24 . A method for stimulating ovulation in an equine, comprising administering the modified glycoprotein hormone of  claim 20  to said equine.