Implant having controlled generation rate of reactive oxygen species and method of controlling generation of reactive oxygen species using the same

Abstract

Provided is an implant having a controlled generation rate of reactive oxygen species and a method of controlling generation of reactive oxygen species using the same. The implant having a controlled generation rate of reactive oxygen species according to the present invention includes a body formed of a metallic material and having a groove, a first filling metal filling one region of the groove, and a second filling metal filling the groove on the first filling metal, wherein the second filling metal has an ionization tendency different from that of the first filling metal.

What is claimed is: 
     
         1 . A method of controlling a generation rate of reactive oxygen species using an implant comprising a first filling metal and a second filling metal both having higher ionization tendencies than that of a body, the method comprising:
 a first step of generating reactive oxygen species by ionization of the second filling metal caused by galvanic corrosion between the second filling metal and the body; and   a second step of generating reactive oxygen species in a concentration different from a concentration of reactive oxygen species obtained in the first step by ionization of the first filling metal caused by galvanic corrosion between the first filling metal and the body after the first step, and   the first filling metal and the second filling metal have different ionization tendencies.   
     
     
         2 . The method of  claim 1 , wherein the ionization tendency of the second filling metal is higher than that of the first filling metal, and
 the concentration of reactive oxygen species generated in the second step is lower than the concentration of reactive oxygen species generated in the first step.   
     
     
         3 . A method of controlling a generation rate of reactive oxygen species using an implant having a groove formed to have different cross-sectional areas and filled with a filling metal having a higher ionization tendency than that of a body, the method comprising:
 a first step of generating reactive oxygen species by ionization of the filling metal having a first cross-sectional area; and   a second step of generating reactive oxygen species in a concentration different from a concentration of reactive oxygen species obtained in the first step by ionization of the filling metal having a second cross-sectional area different from the first cross-sectional area after the first step.   
     
     
         4 . The method of  claim 3 , wherein the concentration of reactive oxygen species generated in the second step is lower than the concentration of reactive oxygen species generated in the first step. 
     
     
         5 . A method of manufacturing an implant having a controlling generation rate of reactive oxygen species, the method comprising:
 preparing a body having a groove;   filling one region inside the groove with a first filling metal; and   filling another region on the first filling metal with a second filling metal,   wherein the second filling metal has an ionization tendency different from an ionization tendency of the first filling metal.   
     
     
         6 . The method of  claim 5 , wherein the second filling metal has a higher ionization tendency than that of the first filling metal. 
     
     
         7 . The method of  claim 5 , wherein the fillings with the first and second filling metals are performed by directly inserting the first and second filling metals into the groove. 
     
     
         8 . The method of  claim 5 , wherein the fillings with the first and second filling metals comprise:
 injecting a molten fluid of the first filling metal into the groove and solidifying the molten fluid; and   injecting a molten fluid of the second filling metal onto the first filling metal and solidifying the molten fluid.   
     
     
         9 . The method of  claim 5 , wherein the fillings with the first and second filling metals comprise:
 inserting a powder of the first filling powder to the groove and sintering the powder; and   inserting a powder of the second filling metal onto the first filling metal and sintering the powder.   
     
     
         10 . The method of  claim 5 , wherein the fillings with the first and second filling metals comprise:
 sequentially inserting powders of the first filling metal and the second filling metal to the groove and sintering the powders.   
     
     
         11 . A method of manufacturing an implant having a controlled generation rate of reactive oxygen species, the method comprising:
 preparing a body having a groove; and   filling at least one region of the groove with a filling metal,   wherein the groove comprises an upper region having a larger cross-sectional area than a cross-sectional area of a lower region, and   the filling of the groove with the filling metal comprises filling the groove with the filling metal up to a portion of the upper region.   
     
     
         12 . The method of  claim 11 , wherein the filling of the groove with the filling metal is performed by directly inserting the filling metal into the groove. 
     
     
         13 . The method of  claim 11 , wherein the filling of the groove with the filling metal comprises injecting a molten fluid of the filling metal into the groove and solidify the molten fluid. 
     
     
         14 . The method of  claim 11 , wherein the filling of the groove with the filling metal comprises injecting a powder of the filling metal to the groove and sintering the powder.