Implantable device for organ operation modulation

Abstract

A system for modulating operation of an organ in real time by controlling illumination of one or more light components is provided. The system includes an external device comprising a processing unit and a power supply configured to transmit stimulation parameters, a wireless implantable device comprising, a sensor configured to detect, in real time, activity data from a tissue cluster of an organ, a stimulator including a plurality of light components corresponding to at least a first wavelength and a second wavelength and a flexible elastomer coupled to the plurality of light components, and a transceiver configured to transmit the activity data to the external device, wherein the stimulator is configured to illuminate, based on the stimulation parameters, one of the plurality of light components coupled to the flexible elastomer, wherein the processing unit is configured to update the stimulation parameters based on the activity data.

1 . A system comprising:
 an external device comprising a processing unit and a power supply configured to transmit stimulation parameters;   a wireless implantable device comprising:   a sensor configured to detect, in real time, activity data from a tissue cluster of an organ, wherein the activity data comprises a quantity of reactive oxygen species of the organ and the sensor detects an auto-fluorescence value from the tissue cluster of the organ, wherein the auto-fluorescence value is usable for determining the quantity of reactive oxygen species of the organ;   a stimulator including a plurality of light components corresponding to at least a first wavelength and a second wavelength and a flexible elastomer coupled to the plurality of light components; and   a transceiver configured to transmit the activity data to the external device,   wherein the stimulator is configured to illuminate, based on the stimulation parameters, one of the plurality of light components coupled to the flexible elastomer, and   wherein the processing unit is configured to update the stimulation parameters based on the activity data.   
     
     
         2 . (canceled) 
     
     
         3 . (canceled) 
     
     
         4 . The wireless implantable device of  claim 1 , wherein the sensor detecting, in real time, the activity data from the tissue cluster of the organ includes the sensor detecting an additional auto-fluorescence value of at least one of a plurality of molecules. 
     
     
         5 . The wireless implantable device of  claim 4 , wherein the plurality of molecules include proteins, arachidonic acid, and flavins. 
     
     
         6 . The wireless implantable device of  claim 1 , wherein one of the plurality of light components includes a light emitting diode that is configured to emit a first light. 
     
     
         7 . The wireless implantable device of  claim 6 , wherein the first light corresponds to a wavelength of 488 nanometers. 
     
     
         8 . The wireless implantable device of  claim 1 , wherein another one of the plurality of light components includes an additional light emitting diode that is configured to emit a second light. 
     
     
         9 . The wireless implantable device of  claim 8 , wherein the second light corresponds to a wavelength of 405 nanometers. 
     
     
         10 . The wireless implantable device of  claim 1 , wherein the plurality of light components being coupled to the flexible elastomer includes a first light component embedded in a first portion of the flexible elastomer and at least a second light component embedded in a second portion of the flexible elastomer. 
     
     
         11 . The wireless implantable device of  claim 1 , wherein the flexible elastomer is configured to attach to the tissue cluster of the organ. 
     
     
         12 . A method comprising:
 detecting, in real time, activity data from a tissue cluster of an organ, wherein the activity data comprises a quantity of reactive oxygen species of the organ and the sensor detects an auto-fluorescence value from the tissue cluster of the organ, wherein the auto-fluorescence value is usable for determining the quantity of reactive oxygen species of the organ;   transmitting the activity data to an external device;   receiving, from the external device, stimulation parameters for illumination of at least one of a plurality of light components, the plurality of light components coupled to a flexible elastomer; and   illuminating, based on the stimulation parameters, at least one of the plurality of light components.   
     
     
         13 . (canceled) 
     
     
         14 . (canceled) 
     
     
         15 . The method of claim  14412 , wherein the detecting, in real time, of the activity data from the tissue cluster of the organ includes detecting, in real time, an additional auto-fluorescence value of at least one of a plurality of molecules, the plurality of molecules including proteins, arachidonic acid, and flavins. 
     
     
         16 . The method of  claim 12 , wherein one of the plurality of light components includes a light emitting diode that is configured to emit a first light. 
     
     
         17 . The method of  claim 16 , wherein the first light corresponds to a wavelength of 488 nanometers. 
     
     
         18 . A method for monitoring of cardiac-arrest risk levels and physiological activity of an individual and modulating sympathetic nerve activity based on the cardiac-arrest risk levels and the physiological activity, the method is implemented by a computing device, the method comprising:
 receiving, in real time, cardiac risk data associated with the individual;   receiving, in real time, physiological data associated with the individual;   analyzing using an artificial intelligence engine, in real time, the cardiac risk data and the physiological data associated with the individual;   determining based on the analyzing, in real time, a cardiac risk level of the individual and a physiological activity level of the individual;   generating first stimulation parameters for reducing the sympathetic nerve activity responsive to determining that the cardiac risk level exceeds a cardiac-risk metric;   generating second stimulation parameters for increasing sympathetic nerve activity based on:
 determining, using the artificial intelligence engine, that the physiological activity level of the individual satisfies a physiological activity metric, and 
 determining that the cardiac risk level does not exceed a cardiac risk metric; and 
   transmitting at least one of the first stimulation parameters and the second stimulation parameters to an implantable device.   
     
     
         19 . The method of  claim 18 , wherein the implantable device is a neurophotonic device. 
     
     
         20 . The method of  claim 18 , wherein the cardiac risk data includes one or more of reactive oxygen species levels, arrhythmias, ectopic heart beats, and blood pressure and the physiological data includes respiration rate, pulse rate, activity levels, and metabolite levels.