Devices for bleeding reduction and methods of making and using the same

Abstract

In some embodiments, a system includes an applicator pad, an application device (e.g., a grip), and a reservoir. The grip can be releasably couplable to the applicator pad and configured to dispose the applicator pad against a wound of a subject such that pressure can be transferred to the wound via the applicator pad to enhance hemostasis. The reservoir can be configured to contain medication to be released to the wound via the applicator pad.

1 - 77 . (canceled) 
     
     
         78 . A system, comprising:
 an applicator pad;   a grip releasably couplable to the applicator pad and configured to dispose the applicator pad against a wound of a subject such that pressure can be transferred to the wound via the applicator pad to enhance hemostasis;   a reservoir configured to contain medication to be released to the wound via the applicator pad; and   a release mechanism coupled to the reservoir and configured to transition from a closed condition to an open condition to allow medication to flow from the reservoir and to the applicator pad via a fluid coupling in response to a pressure above a threshold pressure applied to the reservoir.   
     
     
         79 . The system of  claim 78 , wherein the reservoir is a first reservoir, and further comprising a second reservoir included in the applicator pad. 
     
     
         80 . The system of  claim 78 , wherein the applicator pad includes a pad retainer configured to maintain the applicator pad in contact with the wound after the grip is decoupled from the applicator pad. 
     
     
         81 . The system of  claim 78 , wherein the grip includes a first portion and a second portion, the second portion configured to be moved relative to the first portion to cause liquid to be released from the reservoir to the applicator pad. 
     
     
         82 . The system of  claim 78 , wherein the medication includes an antifibrinolytic. 
     
     
         83 . The system of  claim 78 , wherein the medication includes at least one of an antifibrinolytic, a vasoconstrictor, an antibiotic, an anti-infectant, or a steroid. 
     
     
         84 . The system of  claim 78 , wherein the medication is tranexamic acid (TXA). 
     
     
         85 . The system of  claim 84 , wherein the applicator pad includes a material that is non-reactive with TXA. 
     
     
         86 . The system of  claim 85 , wherein the applicator pad includes a foamed polymer. 
     
     
         87 . The system of  claim 85 , wherein the applicator pad includes a natural fiber. 
     
     
         88 . The system of  claim 78 , wherein the grip includes a plate disposed on a distal end of the grip and configured to apply a distributed, uniform force to the applicator pad when pressed toward the wound with a force orthogonal to the skin. 
     
     
         89 . The system of  claim 78 , wherein a sidewall portion of the grip is configured to be urged toward the reservoir to transition the reservoir from a closed condition to an open condition. 
     
     
         90 . The system of  claim 78 , wherein the applicator pad includes a backing having a convex distal surface such that the applicator pad has a convex distal surface, the backing being more rigid than a distal portion of the applicator pad coupled to the backing. 
     
     
         91 . A system, comprising:
 an applicator pad;   a grip releasably couplable to the applicator pad and configured to dispose the applicator pad against a wound of a subject such that pressure can be transferred to the wound via the applicator pad to enhance hemostasis;   a first reservoir included in the applicator pad and configured to contain medication to be released to the wound via the applicator pad;   a second reservoir; and   a fluid coupling configured such that liquid can flow from the second reservoir to the applicator pad via the fluid coupling.   
     
     
         92 . The system of  claim 91 , wherein the medication includes an antifibrinolytic. 
     
     
         93 . The system of  claim 91 , wherein the medication includes at least one of an antifibrinolytic, a vasoconstrictor, an antibiotic, an anti-infectant, or a steroid. 
     
     
         94 . The system of  claim 91 , wherein the medication is tranexamic acid (TXA). 
     
     
         95 . A system, comprising:
 an applicator pad including a foamed polymer;   a backing coupled to the applicator pad, the backing being more rigid than the applicator pad;   a grip releasably couplable to the applicator pad and configured to dispose the applicator pad against a wound of a subject such that pressure can be transferred to the wound via the applicator pad to enhance hemostasis; and   a reservoir containing tranexamic acid (TXA) to be released to the wound via the applicator pad.   
     
     
         96 . The system of  claim 95 , wherein the backing has a convex distal surface. 
     
     
         97 . The system of  claim 95 , wherein the grip includes a first portion and a second portion, the second portion configured to be moved relative to the first portion to cause liquid to be released from the reservoir to the applicator pad. 
     
     
         98 . The system of  claim 97 , wherein:
 the grip is configured to dispose the applicator pad against the wound of the subject such that a force can be applied to the grip in a first direction to transfer the pressure to the wound via the applicator pad,   the second portion is configured to be moved in a second direction relative to the first portion to cause the liquid to be released from the reservoir of the applicator pad, and   the first direction is different from the second direction.   
     
     
         99 . A system, comprising:
 an applicator pad;   a grip releasably couplable to the applicator pad and configured to dispose the applicator pad against a wound of a subject such that pressure can be transferred to the wound via the applicator pad to enhance hemostasis, the grip including a housing defining an interior; and   a reservoir disposed within the interior and configured to contain medication to be released to the wound via the applicator pad,   a portion of the housing configured to be urged toward the reservoir to transition the reservoir from a closed condition to an open condition to allow medication to flow from the reservoir to the applicator pad.   
     
     
         100 . The system of  claim 99 , wherein:
 the grip is configured to dispose the applicator pad against the wound of the subject such that a force can be applied to the grip in a first direction to transfer the pressure to the wound via the applicator pad,   the portion of the housing is configured to be moved in a second direction relative to the first portion to transition the reservoir from the closed condition to the open condition, and   the first direction is different from the second direction.   
     
     
         101 . The system of  claim 99 , wherein the portion of the housing is a sidewall portion. 
     
     
         102 . The system of  claim 99 , wherein the medication includes an antifibrinolytic. 
     
     
         103 . The system of  claim 99 , wherein the medication includes at least one of an antifibrinolytic, a vasoconstrictor, an antibiotic, an anti-infectant, or a steroid. 
     
     
         104 . The system of  claim 99 , wherein the medication is tranexamic acid (TXA).