US2023322774A1PendingUtilityA1

Dimethyl amino azetidine amides as jak inhibitors

Assignee: THERAVANCE BIOPHARMA R&D IP LLCPriority: Sep 4, 2018Filed: Mar 9, 2023Published: Oct 12, 2023
Est. expirySep 4, 2038(~12.1 yrs left)· nominal 20-yr term from priority
C07D 471/04A61K 31/437A61P 11/00A61P 37/06
79
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Claims

Abstract

The invention provides compounds of formula (I):where the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds and methods of using such compounds to treat respiratory diseases.

Claims

exact text as granted — not AI-modified
1 .- 23 . (canceled) 
     
     
         24 . A pharmaceutical composition comprising a compound of formula 1: 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically-acceptable salt thereof, and a pharmaceutically-acceptable carrier. 
     
     
         25 . The pharmaceutical composition of  claim 24 , wherein the pharmaceutical composition is administered by inhalation. 
     
     
         26 . The pharmaceutical composition of  claim 24 , wherein the pharmaceutical composition is administered by inhalation using a nebulizer inhaler. 
     
     
         27 . A pharmaceutical composition comprising a compound of formula 1: 
       
         
           
           
               
               
           
         
       
       and a pharmaceutically-acceptable carrier. 
     
     
         28 . The pharmaceutical composition of  claim 27 , wherein the pharmaceutical composition is administered by inhalation. 
     
     
         29 . The pharmaceutical composition of  claim 27 , wherein the pharmaceutical composition is administered by inhalation using a nebulizer inhaler.

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