Compositions and methods

Abstract

The present invention provides an amorphous solid for use in aerosol generation, the amorphous solid comprising: about 1 to about 50 wt % cannabidiolic acid (CBDA); about 10 to about 80 wt % aerosol-former material; gelling agent; and optionally filler, wherein the amount of gelling agent and optional filler taken together is from about to about 60 wt %; wherein the wt % values are calculated on a dry weight basis.

1 . An amorphous solid for use in aerosol generation, the amorphous solid comprising:
 about 1 to about 50 wt % cannabidiolic acid (CBDA);   about 10 to about 80 wt % aerosol-former material;   gelling agent; and   optionally filler, wherein the amount of gelling agent and optional filler taken together is from about 10 to about 60 wt %;   wherein the wt % values are calculated on a dry weight basis.   
     
     
         2 . The amorphous solid of  claim 1  comprising about 1 to about 12 wt % CBDA. 
     
     
         3 . The amorphous solid of  claim 1  comprising about 15 to about 50 wt % CBDA. 
     
     
         4 . The amorphous solid of any of  claims 1  to  3  comprising about 60 to about 80 wt % aerosol-former material. 
     
     
         5 . The amorphous solid of any of  claims 1 - 4  comprising about  15  to about  40  wt % gelling agent. 
     
     
         6 . The amorphous solid of any of  claims 1 - 5 , wherein the gelling agent comprises or is one or more compounds selected from polysaccharide gelling agents, such as alginate, pectin, starch or a derivative thereof, cellulose or a derivative thereof, pullulan, carrageenan, agar and agarose; gelatin; gums, such as xanthan gum, guar gum and acacia gum; silica or silicone compounds, such as polydimethylsiloxane (PDMS) and sodium silicate; clays, such as kaolin; and polyvinyl alcohol. 
     
     
         7 . The amorphous solid of  claim 6 , wherein the polysaccharide gelling agent is selected from alginate and a cellulose derivative. 
     
     
         8 . The amorphous solid of  claims 6 - 8 , wherein the cellulose derivative is selected from hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethylcellulose (CMC), hydroxypropyl methylcellulose (HPMC), methyl cellulose, ethyl cellulose, cellulose acetate (CA), cellulose acetate butyrate (CAB), and cellulose acetate propionate (CAP). 
     
     
         9 . The amorphous solid of any of  claims 1 - 8 , wherein the gelling agent is not crosslinked. 
     
     
         10 . The amorphous solid of any of  claims 1 - 9 , wherein the gelling agent is CMC. 
     
     
         11 . The amorphous solid of any of  claims 1 - 6 , wherein the gelling agent comprises guar gum. 
     
     
         12 . The amorphous solid of any of  claims 1 - 11 , wherein the aerosol-former material comprises (or is) one or more of glycerol, propylene glycol, diethylene glycol, triethylene glycol, tetraethylene glycol, 1,3-butylene glycol, erythritol, meso-Erythritol, ethyl vanillate, ethyl laurate, a diethyl suberate, triethyl citrate, triacetin, a diacetin mixture, benzyl benzoate, benzyl phenyl acetate, tributyrin, lauryl acetate, lauric acid, myristic acid, and propylene carbonate. 
     
     
         13 . The amorphous solid of any of  claims 1 - 12  wherein the aerosol-former material comprises or is glycerol or a combination of glycerol and propylene glycol. 
     
     
         14 . An aerosol-generating material comprising the amorphous solid of any of  claims 1 - 13 . 
     
     
         15 . The aerosol-generating material of  claim 14 , comprising from about 50-100 wt % wet weight basis (WWB) of the amorphous solid. 
     
     
         16 . A consumable for use in a non-combustible aerosol provision device, the consumable comprising the aerosol-generating material of  claim 14  or  claim 15 . 
     
     
         17 . A non-combustible aerosol provision system comprising the consumable of  claim 16  and a non-combustible aerosol provision device. 
     
     
         18 . A method of forming the amorphous solid of any of  claims 1  to  13 , the method comprising:
 (a) providing a slurry comprising the CBDA, the gelling agent, the aerosol-former material, a solvent and any optional further components of the amorphous solid; 
 (b) forming a layer of the slurry; 
 (c) optionally setting the layer of the slurry; and 
 (d) drying the slurry to form the amorphous solid. 
 
     
     
         19 . A slurry comprising:
 about 1 to about 50 wt % CBDA;   about 10 to about 80 wt % aerosol-former material;   gelling agent; and   optionally filler, wherein the amount of gelling agent and optional filler taken together is from about 10 to about 60 wt %;   wherein the wt % values are calculated on a dry weight basis; and   a solvent.   
     
     
         20 . The method of  claim 18  or the slurry of  claim 19 , wherein the solvent comprises water. 
     
     
         21 . A method of generating an aerosol by heating the amorphous solid of any of  claims 1  to  13  in a non-combustible aerosol provision device.