US2023287037A1PendingUtilityA1
3,3 disubstituted 19-nor pregnane compounds, compositions, and uses thereof
Est. expiryOct 14, 2031(~5.2 yrs left)· nominal 20-yr term from priority
Inventors:Ravindra B. UpasaniBenny C. Askew, Jr.Boyd L. HarrisonFrancesco G. SalituroAlbert Jean Robichaud
C07J 43/003C07J 5/0015C07J 7/002C07J 7/0085C07J 31/006A61P 25/00A61P 25/04A61P 25/08A61P 25/14A61P 25/16A61P 25/18A61P 25/20A61P 25/22A61P 25/24A61P 25/28A61P 27/16A61P 9/10C07J 7/008C07J 9/005
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Claims
Abstract
Provided herein are 3,3-disubstituted 19-nor-steroidal compounds according to Formula (I) and (III): where R 1 , R 2 , R 3 , R 3′ , R 4 , R 6a , R 6a , R 11a , and R 11b are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, insomnia, anxiety, depression, traumatic brain injury (TBI), stress, and epilepsy.
Claims
exact text as granted — not AI-modifiedWe claim:
1 - 27 . (canceled)
28 . A compound of the formula:
or a pharmaceutically acceptable salt thereof.
29 . A process for preparing a compound of the formula:
or a pharmaceutically acceptable salt thereof,
the process comprising treating a compound of Formula 8b:
with a halogenating reagent, in the presence of an acid catalyst and an alcohol.
30 . The process of claim 29 , wherein the halogenating agent is bromine.
31 . The process of claim 29 , wherein the acid catalyst is hydrobromic acid.
32 . The process of claim 29 , wherein the alcohol is methanol.Join the waitlist — get patent alerts
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