Vitamin formulation

Abstract

Solid particles comprising at least one fat-soluble vitamin are provided and exhibit better stability when compressed into tablets.

1 . Solid particles comprising:
 at least 20 wt-%, based on the total weight of the solid particles, of least one fat soluble vitamin,   at least one emulsifier, and   at least one non-reducing sugar.   
     
     
         2 . The solid particles according to  claim 1 , wherein the at least one non-reducing sugar is present in an amount of 5-55 wt.%, based on the total weight of the solid particles, of at least one non-reducing sugar. 
     
     
         3 . The solid particles according to  claim 1 , wherein the at least one reducing sugar comprises trehalose. 
     
     
         4 . The solid particles according to  claim 2 , wherein the at least one non-reducing sugar is present in an amount of 10 - 50 wt.%, based on the total weight of the solid particles. 
     
     
         5 . The solid particles according to  claim 1 , wherein the fat soluble vitamin is vitamin A and/or derivatives thereof. 
     
     
         6 . The solid particles according to  claim 5 , wherein the fat soluble vitamin is selected from the group consisting of vitamin A acetate and vitamin A palmitate. 
     
     
         7 . The solid particles according to  claim 1 , wherein the at least one fat-soluble vitamin is present in an amount of 20 - 75 wt.%, based on the total weight of the solid particles. 
     
     
         8 . The solid particles according to  7 , wherein the at least one fat-soluble vitamin is present in an amount of 20 - 70 wt.%, based on the total weight of the solid particles. 
     
     
         9 . The solid particles according to  claim 1 , wherein the at least one emulsifier is present in an amount of 20 - 70 wt.%, based on the total weight of the solid particles. 
     
     
         10 . The solid particles according to  claim 1 , wherein the at least emulsifier is selected from the group consisting of modified food starch and gum acacia. 
     
     
         11 . The solid particles according to  claim 1 , wherein the solid particles have a size (Dv90) between 50-1000 µm. 
     
     
         12 . The solid particles according to  claim 1 , wherein the solid particles have a size (Dv90) between 100-800 µm. 
     
     
         13 . A compressed tablet comprising the solid particles according to  claim 1 . 
     
     
         14 . The compressed tablet according to  claim 13 , wherein the solid particles comprise:
 (i) at least 20 wt.%, based on the total weight of the solid particles, of least one fat soluble vitamin selected from the group consisting of vitamin A, vitamin A acetate and vitamin A palmitate,   (ii) 20 - 70 wt.%, based on the total weight of the solid particles, of at least one emulsifier selected from the group consisting of modified food starch and gum acacia, and   (iii) 5 - 55 wt.%, based on the total weight of the solid particles, of trehalose as a non-reducing sugar.   
     
     
         15 . The compressed tablet according to  claim 14 , wherein the trehalose is present in an amount of 10 - 50 wt.%, based on the total weight of the solid particles. 
     
     
         16 . The compressed tablet according to  claim 14 , wherein the at least one fat-soluble vitamin is present in an amount of 20 - 75 wt.%, based on the total weight of the solid particles. 
     
     
         17 . The compressed tablet according to  claim 14 , wherein the at least one fat-soluble vitamin is present in an amount of 25 - 70 wt.%, based on the total weight of the solid particles. 
     
     
         18 . The compressed tablet according to  claim 14 , wherein the solid particles have a size (Dv90) between 50-1000 µm. 
     
     
         19 . The compressed table according to  claim 14 , wherein the solid particles have a size (Dv90) between 100-800 µm. 
     
     
         20 . A method of forming a compressed tablet comprising subjecting the solid particles according to  claim 1  to a pressure of at least 5 kN to thereby form the compressed tablet comprised of the solid particles. 
     
     
         21 . The method according to  claim 20 , wherein the compression pressure is between 5 and 40 kN.