Methods and devices for simultaneous optical irradiation and oscillating magnetic field radiation of a target

Abstract

The present disclosure is generally directed to methods and devices for the precise and simultaneous optical irradiation and oscillating magnetic field radiation of a target, such as mammalian cells and/or nanostructures.

What is claimed is: 
     
         1 . An incubator-actuator device comprising:
 a sample chamber,   a magnetic field generating coil, and   a light-emitting diode (LED) placement cage;   wherein the incubator-actuator device is configured for simultaneous optical irradiation and oscillating magnetic field irradiation of a mammalian cell;   wherein the simultaneous optical irradiation and oscillating magnetic field irradiation occur within the incubator-actuator device.   
     
     
         2 . The device of  claim 1 , wherein the optical irradiation occurs at a wavelength between about 450 nm to about 675 nm. 
     
     
         3 . The device of  claim 1 , wherein simultaneously exposing the mammalian cell comprises simultaneously initiating both the optical irradiation and the oscillating magnetic field irradiation. 
     
     
         4 . An incubator-actuator device comprising:
 a sample chamber,   a magnetic field generating coil, and,   a light-emitting diode (LED) placement cage;   wherein the incubator-actuator device is configured for simultaneous optical irradiation and oscillating magnetic field irradiation of a nanostructure;   wherein the simultaneous optical irradiation and oscillating magnetic field irradiation occur within the incubator-actuator device.   
     
     
         5 . The device of  claim 4 , wherein the optical irradiation occurs at a wavelength between about 450 nm to about 675 nm. 
     
     
         6 . The device of  claim 4 , wherein simultaneously exposing the nanostructure comprises simultaneously initiating both the optical irradiation and the oscillating magnetic field irradiation. 
     
     
         7 . The device of  claim 4 , wherein the nanostructure comprises a shell encapsulating at least one nanoparticle. 
     
     
         8 . The device of  claim 7 , wherein the shell comprises a material selected from the group consisting of polyvinylpyrrolidone (PVP), polyethylene glycol (PEG) and derivatives thereof, poly(N-isopropylacrylamide), tannic acid, dextran, dimercaptosuccinic acid (DMSA) and combinations thereof. 
     
     
         9 . The device of  claim 7 , wherein the at least one nanoparticle is at least one magnetic nanoparticle selected from the group consisting of gold, ferric oxide, magnetite, maghemite, gadolinium-doped cobalt ferrite, and combinations thereof. 
     
     
         10 . The device of  claim 7 , wherein the shell has a thickness of from about 2 nm to about 200 nm. 
     
     
         11 . The device of  claim 7 , wherein the at least one nanoparticle has a size of from about 5 nm to about 100 nm. 
     
     
         12 . The device of  claim 7 , wherein the at least one nanoparticle has a diameter of from about 5 nm to about 270 nm. 
     
     
         13 . A system comprising:
 an incubator-actuator device comprising a sample chamber, a magnetic field generating coil and a light-emitting diode (LED) placement cage; and,   a laser;   wherein the system is configured for simultaneous optical irradiation and oscillating magnetic field radiation of a target;   wherein the simultaneous optical irradiation and oscillating magnetic field irradiation occur within the incubator-actuator device; and   wherein the target is selected from at least one of a mammalian cell and a nanostructure.   
     
     
         14 . The system of  claim 13 , wherein the optical irradiation occurs at a wavelength between about 450 nm to about 675 nm. 
     
     
         15 . The system of  claim 13 , wherein simultaneously exposing the target comprises simultaneously initiating both the optical irradiation and the oscillating magnetic field irradiation. 
     
     
         16 . The system of  claim 13 , wherein the target is a nanostructure and the nanostructure comprises a shell encapsulating at least one nanoparticle. 
     
     
         17 . The system of  claim 16 , wherein the shell has a thickness of from about 2 nm to about 200 nm, and wherein the shell comprises a material selected from the group consisting of polyvinylpyrrolidone (PVP), polyethylene glycol (PEG) and derivatives thereof, poly(N-isopropylacrylamide), tannic acid, dextran, dimercaptosuccinic acid (DMSA) and combinations thereof. 
     
     
         18 . The system of  claim 16 , wherein the at least one nanoparticle is at least one magnetic nanoparticle selected from the group consisting of gold, ferric oxide, magnetite, maghemite, gadolinium-doped cobalt ferrite, and combinations thereof. 
     
     
         19 . The system of  claim 16 , wherein the at least one nanoparticle has a size of from about 5 nm to about 100 nm. 
     
     
         20 . The system of  claim 16 , wherein the at least one nanoparticle has a diameter of from about 5 nm to about 270 nm.