Coated stent

Abstract

An implantable medical device may comprise an elongated tubular body having a scaffolding forming a plurality of cells. A polymeric covering may be disposed over at least a portion of the stent. The covering may include a plurality of voids formed in an outer surface thereof. An extracellular matrix material coating may be disposed over the polymeric covering and within the plurality of voids.

What is claimed is: 
     
         1 . A method of manufacturing an implantable medical device, the method comprising:
 applying a polymeric covering over an elongated tubular body having a scaffolding forming a plurality of cells, the polymeric covering having an outer surface including a micropattern having a plurality of protrusions and a plurality of voids defined therebetween;   applying a liquid extracellular matrix hydrogel over at least a portion of the polymeric covering and within the plurality of voids; and   drying the extracellular matrix hydrogel to form an extracellular matrix material.   
     
     
         2 . The method of  claim 1 , wherein applying the polymeric covering over the elongated tubular body comprises spray coating, electro-spin coating, dip coating, or injection molding the polymeric coating over the scaffolding. 
     
     
         3 . The method of  claim 1 , wherein applying the liquid extracellular matrix hydrogel comprises dip coating. 
     
     
         4 . The method of  claim 1 , wherein applying the liquid extracellular matrix hydrogel comprises spray coating. 
     
     
         5 . The method of  claim 1 , wherein the elongated tubular body and the polymeric covering are bioabsorbable. 
     
     
         6 . The method of  claim 1 , wherein the extracellular matrix material forms a continuous coating over the plurality of voids. 
     
     
         7 . The method of  claim 1 , wherein the extracellular matrix material fills the plurality of voids such that the extracellular matrix material forms a generally planar surface with a top surface of the plurality of protrusions. 
     
     
         8 . The method of  claim 1 , wherein the extracellular matrix material fills the plurality of voids such that a height of the extracellular matrix material is less than a height of the plurality of protrusions. 
     
     
         9 . A method of manufacturing an implantable medical device, the method comprising:
 applying a polymeric covering over an elongated tubular body having a scaffolding forming a plurality of cells, the polymeric covering having an outer surface including a plurality of voids;   applying a liquid extracellular matrix hydrogel over the polymeric covering and within the plurality of voids; and   drying the extracellular matrix hydrogel to form an extracellular matrix material on the outer surface of the polymer covering.   
     
     
         10 . The method of  claim 9 , wherein disposing the polymeric covering over the elongated tubular body comprises electro-spin coating a polymer material over the scaffolding. 
     
     
         11 . The method of  claim 9 , wherein applying the liquid extracellular matrix hydrogel comprises dip coating. 
     
     
         12 . The method of  claim 9 , wherein applying the liquid extracellular matrix hydrogel comprises spray coating. 
     
     
         13 . The method of  claim 9 , wherein the elongated tubular body and the polymeric covering are bioabsorbable. 
     
     
         14 . The method of  claim 9 , wherein the plurality of voids is formed as a monolithic structure with the polymeric coating. 
     
     
         15 . A method of manufacturing an implantable medical device, the method comprising:
 applying a polymeric covering over an elongated tubular body having a scaffolding forming a plurality of cells, the polymeric covering having an outer surface including a micropattern having a plurality of protrusions and a plurality of voids defined therebetween;   generating a liquid extracellular matrix hydrogel;   applying the liquid extracellular matrix hydrogel over at least a portion of the polymeric covering and within the plurality of voids; and   drying the extracellular matrix hydrogel to form an extracellular matrix material.   
     
     
         16 . The method of  claim 15 , wherein the polymeric covering includes an inner layer and an outer layer. 
     
     
         17 . The method of  claim 15 , wherein the plurality of protrusions and the plurality of voids are formed as a monolithic structure with the polymeric coating. 
     
     
         18 . The method of  claim 17 , wherein the plurality of protrusions and the plurality of voids are molded into the outer surface of the polymeric covering. 
     
     
         19 . The method of  claim 15 , wherein the micropattern is formed as a separate layer from the polymeric coating. 
     
     
         20 . The method of  claim 15 , wherein polymeric covering fills the plurality of cells.