Method for producing 3,6-disubstituted-imidazo[1,2-b]pyridazine derivative

Abstract

This disclosure relates to a crystal of 3-{4-[(2R)-2-aminopropoxy]phenyl}-N-[(1R)-1-(3-fluorophenyl)ethyl]imidazo[1,2-b]pyridazin-6-amine adipate.

What is claimed is: 
     
         1 . A crystal of 3-{4-[(2R)-2-aminopropoxy]phenyl}-N-[(1R)-1-(3-fluorophenyl)ethyl]imidazo[1,2-b]pyridazin-6-amine adipate having an X-ray diffraction (XRD) pattern that comprises diffraction peaks having the following diffraction angle 20 values: about 6°, about 18.5°, about 19.5°, about 21°. 
     
     
         2 . The crystal of  claim 1 , wherein the XRD pattern further comprises diffraction peaks having the following diffraction angle 20 values: about 9.7°, about 11.8°, and about 13.8°. 
     
     
         3 . The crystal of  claim 1 , wherein the XRD pattern further comprises diffraction peaks having the following diffraction angle 20 values: about 22.5°, about 23.3°, and about 28.8°. 
     
     
         4 . A crystal of 3-{4-[(2R)-2-aminopropoxy]phenyl}-N-[(1R)-1-(3-fluorophenyl)ethyl]imidazo[1,2-b]pyridazin-6-amine adipate having an X-ray diffraction pattern substantially as depicted in  FIG.  1   .