Stabilized active oxygen-generating antiseptic compositions, irrigation solutions, and articles

Abstract

A stabilized active oxygen-generating antiseptic composition is disclosed including at least one of an antiseptic mixture or an antiseptic polymer. The antiseptic mixture includes a persulfate distributed in a matrix of a sulfate wherein the antiseptic composition is characterized by a ratio of the sulfate to the persulfate of at least 8:2. The antiseptic polymer is formed by the reaction of a sulfate, a persulfate, and amino acid in a reaction solution having a ratio of the sulfate to the persulfate of at least 6:4 and a ratio of the amino acid to the sulfate and the persulfate combined of 1:2 to 2:1. An antiseptic irrigation solution is disclosed including the antiseptic composition dispersed in a solvent. An antiseptic article is disclosed including an article and at least one of the antiseptic composition or an antiseptic coating formed from the antiseptic composition disposed on a surface of the article.

What is claimed is: 
     
         1 . A stabilized active oxygen-generating antiseptic composition, comprising:
 an antiseptic polymer formed by the reaction of a first sulfate, a first persulfate, and amino acid in a reaction solution having a molar ratio of the first sulfate to the first persulfate of at least 6:4 and a molar ratio of the amino acid to the first sulfate and the first persulfate combined of 1:2 to 2:1.   
     
     
         2 . The antiseptic composition of  claim 1 , wherein the first sulfate is selected from the group consisting of Li 2 SO 4 ; Na 2 SO 4 ; K 2 SO 4 ; LiNaSO 4 ; LiKSO 4 ; NaKSO 4 , and combinations thereof. 
     
     
         3 . The antiseptic composition of  claim 2 , wherein the first sulfate-is K 2 SO 4 . 
     
     
         4 . The antiseptic composition of  claim 1 , wherein the first persulfate is a peroxomonosulfate. 
     
     
         5 . The antiseptic composition of  claim 4 , wherein the peroxomonosulfate of the first persulfate is selected from the group consisting of LiHSO 5 ; NaHSO 5 ; KHSO 5 ; LiNaSO 5 ; LiKSO 5 ; NaKSO 5 , Li 2 SO 5 ; Na 2 SO 5 ; K 2 SO 5 , and combinations thereof. 
     
     
         6 . The antiseptic composition of  claim 5 , wherein the peroxomonosulfate of the first persulfate is KHSO 5 . 
     
     
         7 . The antiseptic composition of  claim 1 , wherein the antiseptic polymer includes a molecular weight of less than 2,000 Daltons. 
     
     
         8 . The antiseptic composition of  claim 1 , wherein the molar ratio of the amino acid to the first sulfate and the first persulfate combined is 1:1.1 to 1.1:1. 
     
     
         9 . The antiseptic composition of  claim 1 , wherein the amino acid is selected from the group consisting of histidine, glutamine, alanine, aspartic acid, lysine, glycine, cysteine, arginine, proline, and combinations thereof. 
     
     
         10 . The antiseptic composition of  claim 9 , wherein the amino acid is histidine. 
     
     
         11 . The antiseptic composition of  claim 1 , wherein the antiseptic composition further includes an antiseptic mixture including a matrix of a second sulfate and a second persulfate distributed in the matrix of the second sulfate characterized by a molar ratio of the second sulfate to the second persulfate of at least 8:2. 
     
     
         12 . The antiseptic composition of  claim 11 , wherein the second sulfate has the same chemical composition as the first sulfate and the second persulfate has the same chemical composition as the first persulfate. 
     
     
         13 . The antiseptic composition of  claim 11 , wherein the second sulfate has a distinct chemical composition from the first sulfate and the second persulfate has a distinct chemical composition from the first persulfate. 
     
     
         14 . An antiseptic irrigation solution, comprising:
 a stabilized active oxygen-generating antiseptic composition; and   a solvent in which the stabilized active oxygen-generating antiseptic composition is dispersed,   wherein the antiseptic composition includes an antiseptic polymer formed by the reaction of a first sulfate, a first persulfate, and amino acid in a reaction solution having a molar ratio of the first sulfate to the first persulfate of at least 6:4 and a molar ratio of the amino acid to the first sulfate and the first persulfate combined of 1:2 to 2:1.   
     
     
         15 . The antiseptic irrigation solution of  claim 14 , wherein the first persulfate is a peroxomonosulfate. 
     
     
         16 . The antiseptic irrigation solution of  claim 14 , wherein the antiseptic irrigation solution has a pH of 3.5-7.0. 
     
     
         17 . The antiseptic irrigation solution of  claim 14 , wherein the antiseptic composition further includes an antiseptic dispersal of a second sulfate and a second persulfate characterized by an initial molar ratio of the second sulfate to the second persulfate of at least 8:2. 
     
     
         18 . The antiseptic irrigation solution of  claim 17 , wherein the second persulfate is a peroxomonosulfate. 
     
     
         19 . The antiseptic irrigation solution of  claim 14 , wherein the antiseptic composition produces active oxygen for at least 72 hours following dispersal of the antiseptic composition in the solvent. 
     
     
         20 . The antiseptic irrigation solution of  claim 14 , wherein the antiseptic composition produces active oxygen at a lower rate and for a longer time than a comparative antiseptic irrigation solution having an equal amount (molar) of potassium peroxymonosulfate triple salt in lieu of the antiseptic composition and being otherwise identical. 
     
     
         21 . The antiseptic irrigation solution of  claim 14 , wherein the antiseptic composition produces active oxygen, and the active oxygen includes singlet oxygen. 
     
     
         22 . The antiseptic irrigation solution of  claim 14 , further including dispersed amino acid in the solvent. 
     
     
         23 . The antiseptic irrigation solution of  claim 14 , wherein the antiseptic composition produces active oxygen at a lower rate and for a longer time relative to a comparative composition including an antiseptic dispersal of a second sulfate and a second persulfate characterized by an initial molar ratio of the second sulfate to the second persulfate of at least 8:2 rather than the antiseptic polymer at equal amounts (molar) the first sulfate to the second sulfate and the first persulfate to the second persulfate and being otherwise identical. 
     
     
         24 . An antiseptic article, comprising:
 an article having a surface; and   at least one of:
 a stabilized active oxygen-generating antiseptic composition; or 
 an oxygen-generating antiseptic coating formed from the stabilized active oxygen-generating antiseptic composition, 
   disposed on the surface of the article,   wherein the stabilized active oxygen-generating antiseptic composition includes an antiseptic polymer formed by the reaction of a first sulfate, a first persulfate, and amino acid in a reaction solution having a molar ratio of the first sulfate to the first persulfate of at least 6:4 and a molar ratio of the amino acid to the first sulfate and the first persulfate combined of 1:2 to 2:1.   
     
     
         25 . The antiseptic article of  claim 24 , wherein the surface is an external surface of the article and the antiseptic coating formed from the stabilized active oxygen-generating antiseptic composition is present. 
     
     
         26 . The antiseptic article of  claim 25 , wherein the oxygen-generating antiseptic coating is a monolayer. 
     
     
         27 . The antiseptic article of  claim 25 , wherein the oxygen-generating antiseptic coating is covalently bonded, ionically bonded, or both to the surface of the article. 
     
     
         28 . The antiseptic article of  claim 24 , wherein the article includes a continuous porous substrate and the surface is an internal continuous surface of the continuous porous substrate in fluid communication with an external surface of the article. 
     
     
         29 . The antiseptic article of  claim 24 , wherein the antiseptic article is an implant substrate configured to be surgically disposed in a living organism. 
     
     
         30 . The antiseptic article of  claim 24 , wherein the stabilized active oxygen-generating antiseptic composition further includes an antiseptic mixture including:
 a matrix of a first sulfate; and   a first persulfate distributed in the matrix of the first sulfate,   wherein the antiseptic mixture is characterized by a molar ratio of the first sulfate to the first persulfate of at least 8:2.