Bupropion as a modulator of drug activity

Abstract

Dosage forms, drug delivery systems, and methods related to sustained release of dextromethorphan or improved therapeutic effects are disclosed. Typically, bupropion or a related compound is orally administered to a human being to be treated with, or being treated with, dextromethorphan.

What is claimed is: 
     
         1 . A method of treating generalized anxiety disorder, comprising administering a combination of dextromethorphan and bupropion to a human being in need thereof. 
     
     
         2 . The method of  claim 1 , wherein about 45 mg of the dextromethorphan is orally administered once a day or twice a day. 
     
     
         3 . The method of  claim 1 , wherein about 100 mg to about 120 mg of the bupropion is orally administered once a day or twice a day. 
     
     
         4 . The method of  claim 1 , wherein about 105 mg of the bupropion is orally administered once a day or twice a day. 
     
     
         5 . The method of  claim 1 , wherein the dextromethorphan is orally administered in a dosage form that provides immediate release of the dextromethorphan. 
     
     
         6 . The method of  claim 1 , wherein the bupropion is orally administered in a dosage form that provides sustained release of the bupropion. 
     
     
         7 . The method of  claim 1 , wherein the bupropion and the dextromethorphan are orally administered together in a single dosage form that is orally administered once a day or twice a day.