Oral Care Compositions and Methods of Use

Abstract

This invention relates to oral care compositions comprising arginine or lysine, zinc citrate and zinc oxide, and a fluoride source, as well as to methods of using and of making these compositions.

1 . An oral care composition comprising:
 a. from about 2 to about 5 wt. %, based on the total weight of the oral care composition, of a basic amino acid in free or salt form wherein the amino acid is selected from arginine, lysine, and combinations thereof;   b. from about 0.75 to about 1.25 wt. %, based on the total weight of the oral care composition, of zinc oxide; and   c. from about 0.25 to about 1 wt. %, based on the total weight of the oral care composition, of zinc citrate, wherein the zinc oxide and the zinc citrate are in a weight ratio of zinc oxide to zinc citrate from about 1.5:1 to about 3:1; and   d. a fluoride source.   
     
     
         2 . The oral care composition of  claim 1 , wherein the basic amino acid is arginine or lysine and wherein the arginine or lysine has the L-configuration. 
     
     
         3 . The oral care composition of  claim 1 , wherein the amino acid is arginine or lysine wherein the arginine or lysine is present in an amount corresponding to 0.1% to 15%, based on the total weight of the composition, the weight of the basic amino acid being calculated as free form. 
     
     
         4 . The oral care composition of  claim 1  wherein the amino acid is arginine or lysine wherein the arginine or lysine is present in an amount corresponding to 0.1% to 8%, based on the total weight of the composition, the weight of the basic amino acid being calculated as free form. 
     
     
         5 . The oral care composition of  claim 1 , wherein the amino acid is arginine from about 1.5 to about 8 wt. %, based on the total weight of the composition, the weight of the basic amino acid being calculated as free form. 
     
     
         6 . (canceled) 
     
     
         7 . (canceled) 
     
     
         8 . The oral care composition of  claim 1 , wherein the amino acid is arginine in free form. 
     
     
         9 . The oral care composition of  claim 1 , wherein the amino acid is lysine and wherein the lysine is L-lysine. 
     
     
         10 . (canceled) 
     
     
         11 . The oral care composition of  claim 1 , wherein the amino acid is lysine in free form. 
     
     
         12 . The oral care composition of  claim 1 , wherein the amino acid is arginine or lysine in partially or wholly salt form. 
     
     
         13 . The oral care composition of  claim 1 , wherein the weight ratio of the amount of zinc oxide to zinc citrate is from 2:1 to 4:1, based on the overall composition. 
     
     
         14 . The oral care composition of  claim 13 , wherein the weight ratio of the amount of zinc oxide to zinc citrate is 2:1. 
     
     
         15 . The oral care composition of  claim 1 , wherein the zinc citrate is in an amount of from about 0.25 to about 1 wt. % and zinc oxide may be present in an amount of from about 0.75 to about 1.25 wt. %, based on the total weight of the composition. 
     
     
         16 . The oral care composition of  claim 1 , wherein the zinc citrate is in an amount of about 0.5 wt. % and zinc oxide is present in an amount of about 1 wt. %, based on the total weight of the composition. 
     
     
         17 . The oral care composition of  claim 1 , wherein the fluoride source is sodium fluoride or sodium monofluorophosphate. 
     
     
         18 . The oral care composition of  claim 17 , wherein the sodium fluoride or sodium monofluorophosphate is from 0.1 wt. %-2 wt. % based on the total weight of the composition. 
     
     
         19 . The oral care composition of  claim 17 , wherein the sodium fluoride or sodium monofluorophosphate is a soluble fluoride salt which provides soluble fluoride in amount of about 50 to about 25,000 ppm fluoride. 
     
     
         20 . The composition of  claim 19 , wherein sodium fluoride provides soluble fluoride in an amount of about 1450 ppm. 
     
     
         21 . (canceled) 
     
     
         22 . (canceled) 
     
     
         23 . The composition of  claim 1 , wherein the fluoride source is stannous fluoride. 
     
     
         24 . The oral care composition of  claim 1  further comprising: a preservative selected from: benzyl alcohol, Methylisothizolinone (“MIT”), Sodium bicarbonate, sodium methyl cocoyl taurate (tauranol), lauryl alcohol, and polyphosphate. 
     
     
         25 . The oral care composition of  claim 1  further comprising: benzyl alcohol in an amount of from 0.1-0.8% wt %, based on the total weight of the composition. 
     
     
         26 .- 32 . (canceled)