Methods and compounds for increasing virucidal efficacy in hydroalcoholic systems

Abstract

A topical sanitizing composition for reducing the concentration of non-enveloped viruses on the skin is provided. The topical sanitizing composition includes one or more pH adjusters, at least one carbomer, and at least about 50 wt. % of one or more C1-8 alcohols. The sanitizing composition with pH adjuster and carbomer is able to achieve at least a 3.0 log reduction in the concentration of the non-enveloped virus and in some cases passes the EN 14476 standard.

1 . A method of skin treatment, the method comprising:
 applying a topical sanitizing composition to a skin surface, wherein the topical sanitizing composition comprises:
 at least one pH adjuster; 
 at least one carbomer; and 
 greater than 75 wt. % of one or more C 1-8  alcohols, 
 wherein the weight ratio of pH adjuster/carbomer in the topical sanitizing composition is at least 0.6/1, and 
 wherein the potentiometric pH of the composition is at least 6.1. 
   
     
     
         2 . The method of  claim 1 , wherein the carbomer comprises a cross-linked polyacrylic acid copolymer. 
     
     
         3 . The method of  claim 1 , wherein the pH adjuster comprises one or more of an amine group and an amide group. 
     
     
         4 . The method of  claim 1 , wherein the pH adjuster is selected from the group consisting of aminomethyl propanol, triethanolamine, tetrahydroxypropyl ethylenediamine, or combinations thereof. 
     
     
         5 . The method of  claim 1 , wherein the weight ratio of pH adjuster/carbomer in the topical sanitizing composition is at least 0.7/1. 
     
     
         6 . The method of  claim 1 , wherein the one or more C 1-8  alcohols comprise one or more of methanol, ethanol, propanol, butanol, pentanol, hexanol, and isomers and mixtures thereof. 
     
     
         7 . The method of  claim 6 , wherein the one or more C 1-8  alcohols comprise a mixture of ethanol and isopropanol. 
     
     
         8 . The method of  claim 1 , wherein the one or more C 1-8  alcohols are present in an amount of at least 77.5 wt. %, based on the total weight of the topical sanitizing composition. 
     
     
         9 . The method of  claim 1 , wherein the one or more C 1-8  alcohols are present in an amount of at least 80 wt. %, based on the total weight of the topical sanitizing composition. 
     
     
         10 . The method of  claim 1 , wherein the topical sanitizing composition further comprises one or more humectants selected from the group consisting of propylene glycol, hexylene glycol, 1,4-dihydroxyhexane, 1,2,6-hexanetriol, sorbitol, butylene glycol, caprylyl glycol, propanediol, dipropylene glycol, triethylene glycol, glycerin, polyethylene glycol, ethoxydiglycol, polyethylene sorbitol, glycerol caprylate/caprate, or combinations thereof. 
     
     
         11 . The method of  claim 10 , wherein the humectant is present in an amount up to 20 wt. %, based on the total weight of the topical sanitizing composition. 
     
     
         12 . The method of  claim 1 , wherein the topical sanitizing composition further comprises one or more moisturizing esters selected from the group consisting of cetyl myristate, cetyl myristoleate, diisopropyl sebacate, isopropyl myristate, or combinations thereof. 
     
     
         13 . The method of  claim 1 , wherein:
 the at least one pH adjuster is present in an amount from 0.01 to 2 wt. %, based on the total weight of the composition; and   the weight ratio of pH adjuster/carbomer in the topical sanitizing composition is at least 1/1.   
     
     
         14 . The method of  claim 1 , wherein the at least one carbomer is present in an amount up to 0.5 wt. %, based on the total weight of the composition. 
     
     
         15 . The method of  claim 1 , wherein the method achieves a log reduction against one or more non-enveloped viruses of at least 3.0. 
     
     
         16 . The method of  claim 1 , wherein the method achieves a log reduction against one or more non-enveloped viruses of at least 4.0. 
     
     
         17 . A method of skin treatment, the method comprising:
 applying a topical sanitizing composition to a skin surface, wherein the topical sanitizing composition comprises:
 at least one pH adjuster; 
 an amount up to 0.5 wt. % of at least one carbomer; and 
 at least 77.5 wt. % of one or more C 1-8  alcohols, 
 wherein the weight ratio of pH adjuster/carbomer in the topical sanitizing composition is between 0.6/1 and 2.0/1. 
   
     
     
         18 . The method of  claim 17 , wherein the potentiometric pH of the composition is at least 6.1. 
     
     
         19 . The method of  claim 17 , wherein the composition comprises at least 80 wt. % of one or more C 1-8  alcohols. 
     
     
         20 . The method of  claim 17 , wherein the topical sanitizing composition achieves a log reduction against one or more non-enveloped viruses of at least 4.0.