Laser assisted wound healing protocol and system

Abstract

The present invention provides for devices and methods of treating wounds, including general wounds, gum disease and gingival tissues post scaling/root planning, using a diode laser which generates a beam of light having a wavelength in the visible portion of the electromagnetic spectrum (400 nm-700 nm). Further disclosed are devices and methods capable of stimulating tissue regeneration at the site of a wound.

1 . A system for use in repairing tissue damage subsequent to an acute or chronic injury to an individual, the system comprising:
 a power source; and   an energy source coupled to the power source and configured to emit energy having a power of 0.001 W to 10 W, and a frequency of 40 Hz to 24 GHz;   wherein the energy source is configured to be placed over the tissue damage such that the energy can be directed toward the tissue damage and cause tissue regeneration at the acute or chronic injury.   
     
     
         2 . The system of  claim 1 , wherein the energy source is configured to emit energy having a power of 0.001 W to 3 W and a frequency of 40 Hz to 20 kHz 
     
     
         3 . The system of  claim 1 , wherein the energy source is configured to emit energy having a power of 0.001 W to 3 W and a frequency of 40 Hz to 15 kHz. 
     
     
         4 . The system of  claim 1 , further comprising a substrate, wherein:
 the substrate is configured to induce a biostimulatory response when applied to the tissue damage,   the substrate comprises an aqueous solution, a foam, an ointment, or a gel; and   the substrate is configured to be applied directly on or into the tissue damage with the energy such that a combination of the energy and the substrate causes tissue regeneration at the acute or chronic injury.   
     
     
         5 . The system of  claim 4 , wherein the substrate comprises at least one nanoparticle, wherein the at least one nanoparticle is selected from a group consisting of copper, silver, iron, Fe3Q4, gold, and platinum, or any combination thereof; and at least one additional compound selected from the group consisting of CuCl3, CuCl2, CuCl, FeCl3, FeCl2, AuCl, AuCl2, AuCl3, AgCl, AgCl2 and hyaluronic acid, and any combination thereof. 
     
     
         6 . The system of  claim 4 , wherein the substrate comprises HCl, CuCl, FeCl2, and a phosphate. 
     
     
         7 . The system of  claim 4 , wherein the substrate comprises:
 (i) collagen, wherein the collagen comprises collagen limed, collagen unlimed or collagen supplemented with dense or porous tricalcium phosphate crystals;   (ii) 0.1 g-1 g soluble silver;   (iii) 200 mg-6 g hyaluronic acid;   (iv) 0.1 g-1 g Cu, and   (v) 0.1 g-1 g Fe.   
     
     
         8 . The system of  claim 1 , further comprising a second energy source coupled to the power source, the second energy source configured to generate a beam of light that has a wavelength selected from the group consisting of from about 520 nm to about 570 nm, from about 620 nm to about 750 nm, from about 750 nm to about 1400 nm, and from about 570 nm to about 590 nm. 
     
     
         9 . The system of  claim 1 , further comprising a second energy source coupled to the power source, the second energy source configured to generate a beam of light having a wavelength in a visible portion of an electromagnetic spectrum between 400 nm-1400 nm wavelength. 
     
     
         10 . The system of  claim 9 , wherein the second energy source is fiber optic, comprises a diode laser, or comprises a light emitting diode (LED), and wherein the wavelength is selected from a group consisting of a green wavelength range (520-570 nm), a red wavelength range (620-750 nm) and a yellow wavelength range (570-590 nm). 
     
     
         11 . A method for repairing tissue damage subsequent to an acute or chronic injury to an individual, the method comprising:
 generating power with a power source; and   emitting, with an energy source coupled to the power source, energy having a power of 0.001 W to 10 W, and a frequency of 40 Hz to 24 GHz; and   placing the energy source over the tissue damage such that the energy can be directed toward the tissue damage and cause tissue regeneration at the acute or chronic injury.   
     
     
         12 . The method of  claim 11 , wherein the energy source is configured to emit energy having a power of 0.001 W to 3 W and a frequency of 40 Hz to 20 kHz. 
     
     
         13 . The method of  claim 11 , wherein the energy source is configured to emit energy having a power of 0.001 W to 3 W and a frequency of 40 Hz to 15 kHz. 
     
     
         14 . The method of  claim 11 , further comprising applying a substrate to the tissue damage, wherein:
 the substrate is configured to induce a biostimulatory response when applied to the tissue damage,   the substrate comprises an aqueous solution, a foam, an ointment, or a gel; and   the substrate is configured to be applied directly on or into the tissue damage with the energy such that a combination of the energy and the substrate causes tissue regeneration at the acute or chronic injury.   
     
     
         15 . The method of  claim 14 , wherein the substrate comprises at least one nanoparticle, wherein the at least one nanoparticle is selected from a group consisting of copper, silver, iron, Fe3Q4, gold, and platinum, or any combination thereof; and at least one additional compound selected from the group consisting of CuCl3, CuCl2, CuCl, FeCl3, FeCl2, AuCl, AuCl2, AuCl3, AgCl, AgCl2 and hyaluronic acid, and any combination thereof. 
     
     
         16 . The method of  claim 14 , wherein the substrate comprises HCl, CuCl, FeCl2, and a phosphate. 
     
     
         17 . The method of  claim 14 , wherein the substrate comprises:
 (i) collagen, wherein the collagen comprises collagen limed, collagen unlimed or collagen supplemented with dense or porous tricalcium phosphate crystals;   (ii) 0.1 g-1 g soluble silver;   (iii) 200 mg-6 g hyaluronic acid;   (iv) 0.1 g-1 g Cu, and   (v) 0.1 g-1 g Fe.   
     
     
         18 . The method of  claim 11 , further comprising coupling a second energy source to the power source, and generating, with the second energy source, a beam of light that has a wavelength selected from the group consisting of from about 520 nm to about 570 nm, from about 620 nm to about 750 nm, from about 750 nm to about 1400 nm, and from about 570 nm to about 590 nm. 
     
     
         19 . The method of  claim 11 , further comprising coupling a second energy source to the power source, and generating, with the second energy source, a beam of light having a wavelength in a visible portion of an electromagnetic spectrum between 400 nm-1400 nm wavelength. 
     
     
         20 . The method of  claim 19 , wherein the second energy source is fiber optic, comprises a diode laser, or comprises a light emitting diode (LED), and wherein the wavelength is selected from a group consisting of a green wavelength range (520-570 nm), a red wavelength range (620-750 nm) and a yellow wavelength range (570-590 nm).