Compositions and methods for treating depression

Abstract

Disclosed are a novel combination of specific therapeutics selected from S-adenosyl methionine or a salt thereof, folic acid or a metabolite or salt thereof, and one or more omega-3 fatty acids or salts thereof, useful for a variety of conditions, as discussed herein. Methods of treatment include the treatment of neuropsychiatric conditions, such as depression.

1 - 103 . (canceled) 
     
     
         104 . A method for improving or stabilizing mood of a subject comprising administering to the subject:
 S-adenosyl methionine or a salt thereof;   methyl folate or a salt thereof; and   one or more omega-3 fatty acids or salts thereof, wherein the one or more omega-3 fatty acids or salts thereof comprises at least 60% eicosapentaenoic acid (EPA) or a salt thereof.   
     
     
         105 . The method of  claim 104 , wherein the S-adenosyl methionine or salt thereof is administered in an amount from 200 mg to 4000 mg, inclusive. 
     
     
         106 . The method of  claim 104 , wherein the S-adenosyl methionine or salt thereof is administered in an amount from 800 mg to 1600 mg, inclusive. 
     
     
         107 . The method of  claim 104 , wherein the methyl folate or salt thereof is administered in an amount from 1 mg to 45 mg, inclusive. 
     
     
         108 . The method of  claim 104 , wherein the methyl folate or salt thereof is administered in an amount from 5 mg to 20 mg, inclusive. 
     
     
         109 . The method of  claim 104 , wherein the one or more omega-3 fatty acids or salts thereof is administered in an amount from 500 mg to 5000 mg, inclusive. 
     
     
         110 . The method of  claim 104 , wherein the one or more omega-3 fatty acids or salts thereof is administered in an amount from 800 mg to 1600 mg, inclusive. 
     
     
         111 . The method of  claim 104 , wherein the one or more omega-3 fatty acids or salts thereof are selected from EPA, docosahexaenoic acid (DHA), and combinations thereof. 
     
     
         112 . The method of  claim 104 , wherein:
 the S-adenosyl methionine or salt thereof is administered in an amount from 200 mg to 4000 mg, inclusive;   the methyl folate or salt thereof is administered in an amount from 1 mg to 45 mg, inclusive; and   the one or more omega-3 fatty acids or salts thereof is administered in an amount from 500 mg to 5000 mg, inclusive.   
     
     
         113 . The method of  claim 104 , wherein:
 the S-adenosyl methionine or salt thereof is administered in an amount from 800 mg to 1600 mg, inclusive;   the methyl folate or salt thereof is administered in an amount from 5 mg to 20 mg, inclusive; and   the one or more omega-3 fatty acids or salts thereof is administered in an amount from 800 mg to 1600 mg, inclusive.   
     
     
         114 . The method of  claim 104 , wherein the subject is a human. 
     
     
         115 . The method of  claim 104 , wherein the subject has Major Depressive Disorder. 
     
     
         116 . The method of  claim 104 , wherein the subject does not have Major Depressive Disorder. 
     
     
         117 . The method of  claim 104  further comprising administering vitamin B 12  to the subject. 
     
     
         118 . The method of  claim 104  further comprising administering vitamin E to the subject. 
     
     
         119 . The method of  claim 104 , wherein one or more of the S-adenosyl methionine or salt thereof, methyl folate or salt thereof, and one or more omega-3 fatty acids or salts thereof are present in a composition comprising vitamin E. 
     
     
         120 . A method for improving cognition in a subject comprising administering to the subject:
 S-adenosyl methionine or a salt thereof;   methyl folate or a salt thereof; and   one or more omega-3 fatty acids or salts thereof, wherein the one or more omega-3 fatty acids or salts thereof comprises at least 60% eicosapentaenoic acid (EPA) or a salt thereof.   
     
     
         121 . The method of  claim 120 , wherein the subject has dementia. 
     
     
         122 . The method of  claim 120 , wherein the subject does not have dementia. 
     
     
         123 . A method for promoting happiness and/or reducing depressive symptoms in a subject comprising administering to the subject:
 S-adenosyl methionine or a salt thereof;   methyl folate or a salt thereof; and   one or more omega-3 fatty acids or salts thereof, wherein the one or more omega-3 fatty acids or salts thereof comprises at least 60% eicosapentaenoic acid (EPA) or a salt thereof.   
     
     
         124 . The method of  claim 123 , wherein the subject does not meet the clinical criteria for Major Depressive Disorder and/or does not meet the clinical criteria for treatment with a prescription anti-depressant.