US2023201191A1PendingUtilityA1

Platinum compounds that inhibit constitutive stat3 signaling and induce cell cycle arrest and apoptosis of malignant cells

Assignee: H LEE MOFFITT CANCER CT & RESPriority: Oct 26, 2011Filed: Jan 31, 2023Published: Jun 29, 2023

Est. expiryOct 26, 2031(~5.2 yrs left)· nominal 20-yr term from priority

Inventors:Said M. Sebti Nicholas J. Lawrence James Turkson

A61K 31/495A61K 33/243G01N 33/5091C07D 295/088A61K 33/24

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Claims

Abstract

The subject invention concerns a compound and compositions having activity as an inhibitor of Stat3 protein and methods of using the compound and compositions. In one embodiment, a compound of the invention has the structure shown in formula I, formula II, or formula III. The subject invention also concerns methods of using the compounds and compositions of the invention.

Claims

exact text as granted — not AI-modified

We claim: 
     
         1 . A compound having the structure shown in formula I, formula II, or formula III: 
       
         
           
           
               
               
           
         
       
     
     
         2 . A composition comprising the compound of  claim 1 ; and a carrier, buffer, adjuvant, or a combination of two or more of the foregoing. 
     
     
         3 . A kit comprising the compound of  claim 1 , in one or more containers.

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