Methods of treating inflammatory skin disorders

Abstract

A method for treating, remedying, or preventing inflammatory skin disorders by administering a therapeutically effective dose of at least one an antagonist of a calcitonin gene-related peptide receptor in a pharmaceutically acceptable formulation. The method for treating, remedying, or preventing an inflammatory skin disorder by administering topically and to the prepsoriatic rim a therapeutically effective dose of at least one an antagonist of a calcitonin gene-related peptide receptor in a pharmaceutically acceptable formulation.

What is claimed is: 
     
         1 . A method of treating an inflammatory skin di sease mediated by over-expression of a calcitonin gene-related peptide in an individual in need thereof, the method comprising applying to an edge of a lesion associated with the inflammatory skin disease a therapeutically effective dose of an antagonist of a calcitonin receptor-like receptor. 
     
     
         2 . The method of  claim 1 , wherein the antagonist of the calcitonin receptor-like receptor is selected from the group consisting of 4-sulfinyl benzamide compounds, 3,4-dinitrobenzamide compounds, benzamidazolinyl piperadine compounds, a calcitonin gene-related antagonistic peptide, a derivative of a calcitonin gene-related antagonistic peptide, tryptase active polypeptide, an anti-calcitonin gene-related peptide antibody, BIBN4096BS, and a tryptase stabilizing compound. 
     
     
         3 . The method of  claim 1 , wherein the antagonist of the calcitonin receptor-like receptor is a derivative of a calcitonin gene-related peptide. 
     
     
         4 . The method of  claim 1 , wherein the antagonist of the calcitonin receptor-like receptor is administered topically.