Bilaterally driven closed-loop artificial pancreas

Abstract

A bilaterally driven closed-loop artificial pancreas, includes: a detection module; an infusion module, including: a drug storage unit; a screw and a driving wheel provided with wheel teeth, the driving wheel driving the screw and the screw pushing a piston; a driving unit cooperating with the driving wheel, the driving unit including at least two driving portions; a power unit connected to the driving unit, the power unit outputting two forces in two directions on the driving unit; and a program module imported the total daily dose algorithm and the current insulin infusion algorithm. The artificial pancreas can accurately calculate the TDD value and the current insulin infusion dose, and enhance user experience.

1 . A bilaterally driven closed-loop artificial pancreas, comprising:
 a detection module configured to continuously detect a real-time blood glucose level;   an infusion module, including:
 a drug storage unit; 
 a screw connected to a piston and a driving wheel provided with wheel teeth, the driving wheel drives the screw to move by rotation, pushing the piston, provided in the drug storage unit, forward; 
 a driving unit cooperating with the driving wheel, the driving unit includes at least two driving portions, the driving unit pivots around a pivot shaft, driving the driving portions in different directions, thus pushing the wheel teeth located on the driving wheel respectively, and rotating the driving wheel; 
 a power unit connected to the driving unit, outputting two forces in two directions on the driving unit, making the driving unit pivot in two directions around the pivot shaft; and 
   a program module, which is connected to the detention module and the infusion module, imported a total daily dose algorithm and a current insulin infusion algorithm, and a force output of the power unit is controlled by the program module according to a calculation result of the current insulin infusion algorithm, thereby controlling the infusion module to infuse insulin required.   
     
     
         2 . A bilaterally driven closed-loop artificial pancreas of  claim 1 , wherein
 the driving wheel includes at least two sub-wheels.   
     
     
         3 . A bilaterally driven closed-loop artificial pancreas of  claim 1 , wherein
 the driving wheel includes two sub-wheels, and the pivot shaft is disposed between the two sub-wheels, at least one of the driving portions is provided on each of both sides of the driving unit, and each of the sub-wheels is cooperated with a corresponding one of the driving portions.   
     
     
         4 . A bilaterally driven closed-loop artificial pancreas of  claim 3 , wherein
 the at least one driving portion on each of both sides of the driving unit is two driving portions, and the two driving portions on one of the sides of the driving unit are disposed up and down or left and right.   
     
     
         5 . A bilaterally driven closed-loop artificial pancreas of  claim 1 , wherein
 the program module includes a manual input interface or an automatic detection sub-module, the program module obtains an insulin dose infused per day by users, the insulin dose infused per day by users is manually input into the program module through the manual input interface; or the insulin dose infused per day by users is automatically detected, stored and calculated by the automatic detection sub-module.   
     
     
         6 . A bilaterally driven closed-loop artificial pancreas of  claim 5 , wherein
 the insulin dose infused per day by users includes a total amount of daily infusion dose data, a bolus and basal data infused in different time periods, a temporary basal data and a correction bolus data, or a infusion data after different events.   
     
     
         7 . A bilaterally driven closed-loop artificial pancreas of  claim 6 , wherein
 the total daily dose is obtained by calculating the total amount of daily infusion dose data in the previous two or more days according to the total daily dose algorithm, the total daily dose is an average or median of the insulin dose infused per day by users, and the total daily dose is one variable factor of the current insulin infusion algorithm.   
     
     
         8 . A bilaterally driven closed-loop artificial pancreas of  claim 1 , wherein
 variable factors of the total daily dose algorithm include one or more of user's physical activity status, physiological status, psychological status, and meal status.   
     
     
         9 . A bilaterally driven closed-loop artificial pancreas of  claim 8 , wherein
 the physical activity status includes general body stretching, exercise, or sleep.   
     
     
         10 . A bilaterally driven closed-loop artificial pancreas of  claim 1 ,
 further comprising a motion sensor, which is provided in the detection module, the program module or the infusion module, wherein the motion sensor is used to automatically sense user's physical activity status which is sent to the program module and is one of variable factors of the total daily dose algorithm or the current insulin infusion algorithm.   
     
     
         11 . A bilaterally driven closed-loop artificial pancreas of  claim 10 , wherein
 the motion sensor includes a three-axis acceleration sensor or a gyroscope.   
     
     
         12 . A bilaterally driven closed-loop artificial pancreas of  claim 1 , wherein
 two of the detection module, the program module and the infusion module are connected to each other configured to form a single structure whose attached position on a skin is different from an attached position of a rest one of the detection module, the program module and the infusion module on the skin.   
     
     
         13 . A bilaterally driven closed-loop artificial pancreas of  claim 1 , wherein
 the detection module, the program module and the infusion module are connected together configured to form a single structure which is attached on only one position on a skin.