Ion capture composition for ingestion

Abstract

The invention is directed to ion-capture compositions for ingestion and methods of use thereof. An aspect of the invention is drawn towards a method for selectively capturing at least one ion from the digestive system of a subject, the method comprising administering orally to the subject the ion-capture composition.

What is claimed: 
     
         1 . An ion-capture composition, the composition comprising an ion-capture compound that traps at least one ion from a sample ingested by a subject. 
     
     
         2 . The ion-capture composition of  claim 1 , wherein the compound comprises the formula M′M″ x A 2 B 3 O 12  in NZP form. 
     
     
         3 . The composition of  claim 1 , wherein the composition further comprises a pharmaceutically acceptable carrier. 
     
     
         4 . The composition of  claim 1 , wherein the ion-capture compound comprises microscopic cubic crystals. 
     
     
         5 . The composition of  claim 1 , wherein the ion-capture composition comprises a powder, a granule, a crystal, a suspension, an emulsion, a solution, or a resin. 
     
     
         6 . The composition of  claim 1 , wherein the composition is provided as a powder, a tablet, a capsule, or a pre-made suspension. 
     
     
         7 . The composition of  claim 1 , wherein the composition is formulated for oral administration. 
     
     
         8 . The composition of  claim 1 , wherein the composition is formulated to be ingested by the subject. 
     
     
         9 . The composition of  claim 1 , wherein the at least one ion comprises a monovalent ion. 
     
     
         10 . The composition of  claim 1 , wherein the at least one ion comprises a sodium ion. 
     
     
         11 . The composition of  claim 1 , wherein the at least one ion comprises a sodium ion, lithium ion, a rubidium ion, or a cesium ion. 
     
     
         12 . The composition of  claim 1 , wherein the ion-capture comprises chemical capture, physical capture, or both. 
     
     
         13 . The composition of  claim 1 , wherein the compound captures an ion through ion-exchange, trapping ions within the crystal structure of the compound, adsorption, or chelation. 
     
     
         14 . The composition of  claim 2 , wherein
 M′ comprises a lithium ion, sodium ion, potassium ion, hydrogen ion, hydronium ion, rubidium ion, cesium ion, magnesium ion, calcium ion, strontium ion, barium ion, or a combination thereof;   M″ comprises a sodium ion, potassium ion, hydrogen ion, hydronium ion, or a combination thereof;   A comprises tin, germanium, titanium, zirconium, hafnium, aluminum, chromium, nobium, tantalum, scandium, or combinations thereof;   B comprises phosphorous, silicon, aluminum, sulfur, or mixtures thereof; and   “x” has a value of 0 to about 3.   
     
     
         15 . The composition of  claim 14 , wherein the compound comprises hydrogen zirconium phosphate, or HZr 2 (PO 4 ) 3 . 
     
     
         16 . The composition of  claim 5 , wherein the powder form is combined with a solution, thereby forming a suspension. 
     
     
         17 . A pharmaceutical composition comprising the composition of  claim 1 . 
     
     
         18 . The composition of  claim 16 , wherein the composition comprises a buffer. 
     
     
         19 . A method for capturing at least one ion from a sample ingested by a subject, the method comprising administering orally to the subject the composition of  claim 1 , wherein the composition is administered before, concurrently with, or after the subject ingests a sample comprising one or more ions. 
     
     
         20 . A method for selectively capturing at least one ion from the digestive system of a subject, the method comprising administering orally to the subject the composition of  claim 1 . 
     
     
         21 . The method of  claim 19 , wherein the at least one ion comprises a monovalent ion. 
     
     
         22 . The method of  claim 19 , wherein the at least one ion comprises a sodium ion. 
     
     
         23 . The method of  claim 19 , wherein the at least one ion comprises a sodium ion, lithium ion, a rubidium ion, or a cesium ion. 
     
     
         24 . The method of  claim 19 , wherein the ion-capture comprises chemical capture, physical capture, or both. 
     
     
         25 . The method of  claim 19 , wherein the compound captures an ion through ion-exchange, trapping ions within the crystal structure of the substance, adsorption, or chelation. 
     
     
         26 . The method of  claim 20 , wherein the at least one ion is captured in the digestive tract. 
     
     
         27 . The method of  claim 20 , wherein the subject is administered about 1 milligram to about 100 grams per day. 
     
     
         28 . A method of treating a subject afflicted with a disease, the method comprising administering orally to a subject the composition of  claim 1 . 
     
     
         29 . The method of  claim 28 , wherein the disease comprises heart disease, hypertension, congestive heart failure, chronic kidney disease, kidney failure or edema.