Oral products with nicotine-polymer complex

Abstract

Products containing a nicotine-polymer complex are provided herein, which can optionally further include one or more, different nicotine components. Certain such products are pouched products including an outer water-permeable pouch defining a cavity containing a composition comprising a water-soluble component capable of being released through the water-permeable pouch. The disclosure further provides methods of preparing such products.

1 . A pouched product comprising an outer water-permeable pouch defining a cavity and a composition adapted for oral use situated within the cavity, the pouched product having a total moisture content of about 5% or greater,
 wherein the composition comprises a nicotine component in the form of a nicotine-polymer complex.   
     
     
         2 . The pouched product of  claim 1 , wherein the total moisture content is about 15% or greater. 
     
     
         3 . The pouched product of  claim 1 , wherein the total moisture content is about 25% or greater. 
     
     
         4 . The pouched product of  claim 1 , wherein the nicotine component is the only nicotine component contained within the composition. 
     
     
         5 . The pouched product of  claim 1 , wherein the nicotine component is a first nicotine component and the composition further comprises a second nicotine component selected from the group consisting of nicotine and a nicotine salt. 
     
     
         6 . The pouched product of  claim 1 , wherein the nicotine-polymer complex comprises a polymeric cation exchange resin. 
     
     
         7 . The pouched product of  claim 6 , wherein the polymeric cation exchange resin comprises a polyacrylic polymer. 
     
     
         8 . The pouched product of  claim 1 , wherein the nicotine-polymer complex comprises nicotine polacrilex. 
     
     
         9 . The pouched product of  claim 1 , wherein the nicotine-polymer complex is in the form of particles. 
     
     
         10 . The pouched product  claim 1 , wherein the nicotine-polymer complex is in the form of particles with an average particle size of about 200 microns to about 400 microns. 
     
     
         11 . The pouched product of  claim 1 , wherein the nicotine-polymer complex is in the form of particles that exhibit a bimodal particle size distribution and wherein the bimodal particle size distribution comprises a first mode with a peak at about 75 to about 125 micrometers or about 80 to about 110 micrometers and a second mode with a peak of about 500 to about 1000 micrometers or about 700 to about 1000 micrometers. 
     
     
         12 . The pouched product of  claim 9 , wherein the particles are uncoated. 
     
     
         13 . The pouched product of  claim 9 , wherein the particles are coated with a coating comprising one or more filling components and/or one or more pH adjusters. 
     
     
         14 . The pouched product of  claim 13 , wherein the particles are coated with a coating comprising mannitol and sodium carbonate. 
     
     
         15 . The pouched product of  claim 1 , wherein the composition comprises a pH adjuster selected from sodium hydroxide, potassium hydroxide, calcium hydroxide, magnesium hydroxide, and combinations thereof. 
     
     
         16 . The pouched product of  claim 1 , wherein the composition comprises a calcium salt selected from the group consisting of calcium benzoate, calcium gluconate, calcium glycerol phosphate, calcium lactate, calcium lactate gluconate, and any combination thereof. 
     
     
         17 . A composition, comprising a first nicotine component in the form of a nicotine-polymer complex and a second nicotine component selected from the group consisting of nicotine and a nicotine salt,
 wherein the composition is in the form of a pouched product.   
     
     
         18 . The composition of  claim 17 , wherein the first nicotine component is provided in an amount of about 2% to about 15% by weight and the second nicotine component is provided in an amount of about 0.5% to about 2% by weight, based on the total weight of the composition. 
     
     
         19 . The composition of  claim 17 , wherein nicotine provided from the first nicotine component is present in a higher weight percentage than nicotine provided from the second nicotine component. 
     
     
         20 . The composition of  claim 17 , wherein nicotine provided from the first nicotine component is present in a lower weight percentage than nicotine provided from the second nicotine component. 
     
     
         21 . The composition of  claim 17 , wherein the nicotine-polymer complex comprises nicotine polacrilex. 
     
     
         22 . A method of providing a pouched product comprising an outer water-permeable pouch defining a cavity and a composition adapted for oral use situated within the cavity, with a modified nicotine release profile, comprising:
 incorporating nicotine in the form of a nicotine-polymer complex; and   incorporating water within and/or adding water to the pouched product to give a moist pouched product with a total moisture content of about 5% or greater.