US2023143309A1PendingUtilityA1
Pyrrolobenzodiazepine antibody conjugates
Est. expiryFeb 10, 2036(~9.5 yrs left)· nominal 20-yr term from priority
C07D 487/04A61K 47/68035A61K 47/6851A61K 47/6867A61K 47/6849A61K 47/6855A61P 35/00A61K 47/6889A61K 31/5517A61K 45/06
64
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Claims
Abstract
A conjugate of formula I: L-(D L ) p (I) wherein L is a Ligand unit, D L is a Drug Linker unit of formula II: wherein either: (a) R 10 and R 11 form a nitrogen-carbon double bond between the nitrogen and carbon atoms to which they are bound; or (b) R 11 is OH, and R 10 is: p is an integer of from 1 to 20.
Claims
exact text as granted — not AI-modified1 - 24 . (canceled)
25 . A compound of formula III:
wherein
either:
(a) R 10 and R 11 form a nitrogen-carbon double bond between the nitrogen and carbon atoms to which they are bound; or
(b) R 11 is OH, and R 10 is:
26 . A compound according to claim 25 which is A:
27 . A compound according to claim 25 which is B:
28 . A method of synthesis of a conjugate of formula:
L-(D L ) p (1)
wherein L is a Ligand unit, D L is a Drug Linker unit of formula is:
wherein
either:
(a) R 10 and R 11 form a nitrogen-carbon double bond between the nitrogen and carbon atoms to which they are bound; or
(b) R 11 is OH, and R 10 is:
p is an integer of from 1 to 20
comprising the step of conjugating the compound according to claim 25 with a cell-binding agent.Join the waitlist — get patent alerts
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