Bioprocess System

Abstract

A base station (1) and a bioprocess system (3), wherein said base station (1) comprises: a frame or housing (5), wherein said frame or housing comprises a number of valves (7a-f, 9a-d, 11a-f, 13a-e, 15a-f) into which a disposable tubing set (21) during run of the system is provided such that at least one inlet (23a-j) of the disposable tubing set is connected to at least one outlet (25a-f) of the disposable tubing set via a bioprocess separation device (31) of the bioprocess system (3); and a movable pump holding device (35), which can be provided in at least two different positions, whereof one is within the frame or housing (5) and another is at least partly outside the frame or housing (5) and which comprises at least one pump main body (37), said pump main body comprising a connection (39) configured for connecting to a disposable pump connection part (27) comprised in the disposable tubing set (21).

1 . A base station for a bioprocess system comprising a frame or housing, wherein said frame or housing comprises a number of valves for controlling fluid flow in a disposable tubing set during run of the bioprocess system, such that at least one inlet of the disposable tubing set is connectable to at least one outlet of the disposable tubing set via a bioprocess separation device of the bioprocess system; and wherein a wall of said housing comprises an inlet valve access opening through which access to at least one inlet valve positioned within the frame or housing is achieved. 
     
     
         2 . The base station of  claim 1 , wherein the opening is provided in a bottom part of the frame or housing close to a movable pump holding device when the movable pump holding device is provided inside the frame or housing. 
     
     
         3 . The base station of  claim 2 , wherein the discrete movable pump holding device comprises at least one pump main body, said pump main body comprising a fluid connection configured to be releasably connectable to a pump connection part of the disposable tubing set. 
     
     
         4 . The base station according to  claim 2 , wherein said movable pump holding device comprises a trolley on wheels and wherein said frame or housing comprises a void in a bottom part of the frame or housing for receiving said movable pump holding device. 
     
     
         5 . The base station according to  claim 1 , wherein said frame or housing comprises four walls constituting together with a roof of the frame or housing essentially a box, wherein the valves of the frame or housing are provided on at least three of said four walls and wherein a first wall of said four walls comprises an opening for receiving the movable pump holding device into an empty space of a bottom part of the frame or housing. 
     
     
         6 . The base station according to  claim 5 , wherein outlet valves of the frame or housing are provided on a third wall of said four walls. 
     
     
         7 . The base station according to  claim 1 , wherein at least five separation device valves are provided for receiving the disposable tubing set for controlling feeding of a fluid in the disposable tubing set in either upflow or downflow separation directions or bypass of the bioprocess separation device when connected to the disposable tubing set. 
     
     
         8 . The base station according to  claim 5 , wherein said at least five separation device valves are provided in the third wall of said four walls but at a lower position than the outlet valves. 
     
     
         9 . The base station according to  claim 1 , wherein said frame or housing comprises a holder for a disposable air trap of the disposable tubing set, wherein said holder for a disposable air trap is provided above said inlet valves. 
     
     
         10 . The base station according to  claim 1 , wherein at least one of said valves are pinch valves. 
     
     
         11 . The base station according to  claim 1 , wherein a first group of inlet valves are provided on an upper surface of a frame or housing surrounding the access opening and a second group of inlet valves are provided on a lower surface of the frame or housing surrounding the access opening. 
     
     
         12 . A bioprocess system comprising a base station according to  claim 1 , and a disposable tubing set. 
     
     
         13 . The bioprocess system of  claim 12 , further comprising a movable pump holding device operably connected thereto. 
     
     
         14 . A disposable tubing set for use with the base station of  claim 1 . 
     
     
         15 . The disposable tubing set of  claim 14 , comprising components including:
 at least one inlet tube;   at least one outlet tube;   at least one pump connection part connected to the inlet tubing and configured for being connected to a pump main body;   at least one air trap; and   two separation device connection points for connection to a bioprocess separation device,   
       wherein said components are fluidically interconnected between the at least one outlet tube and the at least one inlet tube. 
     
     
         16 . The disposable tubing set of  claim 15 , wherein said air trap is a disposable air trap, for example a swirl type air trap. 
     
     
         17 . The disposable tubing set of  claim 14 , wherein all of the components of the disposable tubing set are fluidically interconnected and the disposable tubing set can be removed from the base station in one piece. 
     
     
         18 . The disposable tubing set of  claim 14 , wherein the disposable tubing set comprises two separation device connection points, and wherein the disposable tubing is branched such that one branch of the tubing comprises one of the separation device connection points and another branch comprises the other separation device connection point. 
     
     
         19 . The disposable tubing set of  claim 18 , further comprising a bypass branch provided in between the other two branches, and optionally wherein the three branches are collected into one tubing before and after the separation device connection points. 
     
     
         20 . The disposable tubing set of  claim 14 , further comprising one or more of: a filter cartridge; at least one inlet tubing; at least one outlet tubing; at least one disposable pump connection part, for example a pump head which is connected to inlet tubing and configured for being connected to a pump main body; a disposable UV sensor; a disposable flow sensor; a disposable air sensor; a disposable pH meter; a disposable conductivity meter; and/or a disposable pressure meter.