Pyrimidine compound

Abstract

The present invention provides a novel pyrimidine compound represented by Formula [I] and a salt thereof:[in the formula, the symbols are as defined in the specification], which is useful for treating, preventing and/or diagnosing seizure and the like in disease involving epileptic seizure or convulsive seizure (including multiple drug resistant seizure, refractory seizure, acute symptomatic seizure, febrile seizure and status epilepticus), as well as a medical use therefor.

1 . A method for diagnosing seizure in diseases involving epileptic seizure or convulsive seizure (including multiple drug resistant seizure, refractory seizure, acute symptomatic seizure, febrile seizure and status epilepticus), which comprises administering to a human in need thereof an effective amount of a compound represented by Formula [I]: 
       
         
           
           
               
               
           
         
         wherein 
       
       ring A is phenyl, naphthyl or pyridyl;
 R 1  is lower alkyl; 
 R 2  is —O-lower alkyl; 
 R 3  is halogen, lower alkynyl, lower alkyl optionally substituted with halogen, —O-lower alkyl optionally substituted with deuterium or halogen, —S-lower alkyl optionally substituted with halogen, phenyl, pentafluorothio, —CN, —O-benzyl or —Si-mono-, di- or tri-lower alkyl wherein di or tri may be same or different alkyl; 
 L is bond, lower alkylene, —O— or —S—; 
 each of m and n is 0 or 1; 
 q is 0, 1 or 2, and when q is 2, each R 3  independently represents the same or different substituent; and 
    represents single or double bond, 
 or a salt thereof. 
 
     
     
         2 . The method according to  claim 1 , wherein
 ring A is phenyl,   L is —O—, and   n is 0.   
     
     
         3 . The method according to  claim 1 , wherein m is 0. 
     
     
         4 . The method according to  claim 1 , wherein R 3  is halogen, lower alkynyl, lower alkyl or —S-lower alkyl optionally substituted with halogen. 
     
     
         5 . The method according to  claim 1 , wherein 
       
         
           
           
               
               
           
         
         is phenyl, monohalophenyl, dihalophenyl, mono-lower alkynylphenyl or mono-lower alkylphenyl or phenyl substituted with one halogen and one lower alkyl group. 
       
     
     
         6 . A method for diagnosing seizure in diseases involving epileptic seizure or convulsive seizure (including multiple drug resistant seizure, refractory seizure, acute symptomatic seizure, febrile seizure and status epilepticus), which comprises administering to a human in need thereof an effective amount of a compound selected from the group consisting of the following compounds: