Devices, compositions and methods for imaging with raman scattering

Abstract

Methods, systems and computer-accessible medium for imaging a living cell or a living organism with bond-edited compounds using stimulated Raman scattering are disclosed. The method comprises the steps of introducing one or more bond-edited compounds into a live cell or a living organism, and detecting a vibrational tag in the cell or organism with stimulated Raman scattering. Also disclosed are methods for detecting a disease condition in a subject, methods for monitoring treatment for a disease condition, methods for screening an agent, methods for tracing a cellular process in a live cell using bond-edited compounds in combination with stimulated Raman scattering. Also disclosed are a composition for labeling a target cell with at least one bond-edited compound and devices for imaging bond-edited compounds by stimulated Raman scattering.

1 . A method for imaging a living cell or a living organism, comprising:
 introducing an effective amount of a bond-edited compound into a live cell or a living organism, wherein the bond-edited compound comprises a vibrational tag; and   detecting the vibrational tag in the cell or the organism with stimulated Raman scattering (SRS) imaging.   
     
     
         2 - 44 . (canceled)