Use of volatile compounds to modulate the perception of musk

Abstract

The various aspects presented herein relate to the perfumery industry. More particularly, the various aspects presented herein relate to compositions and/or ingredients that increase a subject's perception of musk compounds, methods for intensifying a subject's perception of musk compounds, as well as to the perfumed articles or perfuming compositions comprising as an active ingredient, a compound of Formula (I).

1 . A method for modifying an intensity or a sensitivity of a subject's perception of a musk odor, the method comprising,
 contacting a subject with a positive allosteric modulator of formula (I):   
       
         
           
           
               
               
           
         
       
       in the form of any one of its stereoisomers or a mixture thereof,
 wherein R represents a C 3-11  linear alkyl group optionally substituted by an C 1-4  allyl carboxylester group or a hydroxyl group; a C 4-11  branched alkyl group optionally substituted by a C 1-3  alkoxy group, a C 6-12  linear or branched alkenyl, or alkadienyl group; a phenyl group substituted by one or two C 1-3  alkyl groups; a C 5-8  alicyclic alkenyl group; or a benzyloxymethyl group, and 
 wherein the subject is contacted with the positive allosteric modulator in an amount sufficient to modify an intensity or sensitivity of a perception of the musk odor in the subject. 
 
     
     
         2 . The method of  claim 1 , wherein the method further comprises contacting the subject with at least one musk compound. 
     
     
         3 . The method of  claim 1 , wherein the positive allosteric modulator is incorporated into a perfuming composition. 
     
     
         4 . The method of  claim 3 , wherein the perfuming composition further comprises at least one musk compound. 
     
     
         5 . The method of  claim 3 , wherein the perfuming composition is incorporated into a. consumer product. 
     
     
         6 . The method of  claim 1 , wherein the positive allosteric modulator is incorporated into a consumer product. 
     
     
         7 . The method of  claim 6 , wherein the consumer product further comprises at least one musk compound. 
     
     
         8 . A perfuming composition, which comprises at least one musk compound and a music olfactory receptor inhibitor,
 wherein the musk olfactory receptor inhibitor is selected from the group consisting of: (E)-2-tridecenol, (E)-2-tridecenoic acid, (E)-2-dodecenoic acid, (E)-2-undecenoic acid, (E)-3-(2-methoxyphenyl)prop-2-enal, pentyl valerate, 3-(3-propan-2-ylphenyl)butanal, (+)-(2E)-4-[(3S)-2,3-dimethyltricyclo[2.2.1.0˜2,6˜]hept-3-yl]-2-butenal, trans-5-(4-tert-butylphenyl)-2-methylpent-2-enal, octanal, amandolene pur, citrathal, furfuryl mercaptan, bacdanol, (+−)-(2E)-3-(2-methylspiro[5.5]undec-2-en-1-yl) acrylaldehyde, sandenol, (E)-2-hexenal, (Z)-6-nonen-1-ol, 3-phenylpropanal, (E)-2-(Z)-6-nonadien-1-ol, (E)-dec-4-enal, and aldehyde E.   
     
     
         9 . The perfuming composition of  claim 8 , further comprising a compound of formula (I): 
       
         
           
           
               
               
           
         
         wherein R is a C 3-11  linear alkyl group optionally substituted by an C IA . alkyl carboxylester group or a hydroxyl group; a C 4-11  branched alkyl group optionally substituted by a C 1-3  alkoxy group, a C 6-12  linear or branched alkenyl, or alkadienyl group; a phenyl group substituted by one or two C 1-3  alkyl groups; a C 5-8  alicyclic alkenyl group; or a benzyloxymethyl group. 
       
     
     
         10 . The perfuming composition of  claim 8 . wherein the musk compound is selected from the group consisting of: muscone, muscenone delta, exalione, exaitenone, exaltolide, habanolide, musk xylol, musk ketone, tonalide, vulcanolide, galaxolide, music DTI, cashmeran, muscenone delta, romandolide, and helvetolide. 
     
     
         11 . The perfuming composition of  claim 8 , wherein the musk compound is selected from the group consisting of muscone, muscenone delta, musk xylol, and musk ketone.