Pharmaceutical composition

Abstract

The present invention relates to pharmaceutical compositions having improved stability.

1 - 37 . (canceled) 
     
     
         38 . A stable aqueous pharmaceutical composition comprising a pharmaceutically active compound of formula (II): 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt thereof; 
         wherein the composition comprises:
 2 mg/mL of the compound of formula (II) or a pharmaceutically acceptable salt thereof; 
 a citrate-phosphate buffer; and 
 an isotonicity agent; 
 
         wherein the pH of the composition is from 5.4 to 5.65; and 
         wherein, after storage at 40° C. for 176 days, greater than 95% of the compound of formula (II) or pharmaceutically acceptable salt thereof remains in the composition. 
       
     
     
         39 . The composition of  claim 38 , wherein the isotonicity agent is NaCl. 
     
     
         40 . The composition of  claim 38 , wherein the pH of the composition is 5.5. 
     
     
         41 . A kit, comprising:
 the stable aqueous pharmaceutical composition of  claim 38 ; and   a container for the composition.   
     
     
         42 . A method of treating one or more conditions selected from compromised lactation conditions, labor induction impairment, uterine atony conditions, excessive bleeding, inflammation, pain, abdominal pain, back pain, male and female sexual dysfunction, irritable bowel syndrome (IBS), constipation, gastrointestinal obstruction, autism, stress, anxiety, depression, anxiety disorder, surgical blood loss, post-partum haemorrhage, wound healing, infection, mastitis, placenta delivery impairment, osteoporosis, comprising administering a composition according to  claim 38  to a patient in need thereof. 
     
     
         43 . A method for diagnosis of one or more conditions selected from cancer and placental insufficiency, comprising administering a composition according to  claim 38  to a patient in need thereof. 
     
     
         44 . of treating one or more conditions selected from uterine atony and excessive bleeding following vaginal delivery comprising administering a composition according to  claim 38  to a patient in need thereof.