US2023111081A1PendingUtilityA1

Mitigation of epileptic seizures by combination therapy using benzodiazepines and neurosteroids

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Assignee: UNIV CALIFORNIAPriority: Aug 13, 2012Filed: Nov 19, 2022Published: Apr 13, 2023
Est. expiryAug 13, 2032(~6 yrs left)· nominal 20-yr term from priority
Inventors:Michael A. RogawskiIsaac N. PessahZhengyu CaoPamela J. Lein
A61P 25/08A61K 45/06A61K 31/439A61K 31/5517A61K 31/57A61K 31/5513
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Claims

Abstract

Provided are compositions comprising a benzodiazepine and a neurosteroid, containing one or both of the benzodiazepine and the neurosteroid in a subtherapeutic dose, and administration of such compositions for mitigation of an epileptic seizure. Further provided are compositions comprising a benzodiazepine, a neurosteroid, and an NMDA blocker, and administration of such compositions for mitigation of an epileptic seizure.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . A composition comprising a benzodiazepine and a neurosteroid, wherein the composition comprises one or both of the benzodiazepine and the neurosteroid in a subtherapeutic dose.

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