US2023109968A1PendingUtilityA1

Diarylhydantoin compounds

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Assignee: UNIV CALIFORNIAPriority: May 13, 2005Filed: Jul 13, 2022Published: Apr 13, 2023
Est. expiryMay 13, 2025(expired)· nominal 20-yr term from priority
Inventors:Charles L. SawyersMichael E. JungCharlie D. ChenSamedy OukDerek WelsbieChris TranJohn WongvipatDongwon Yoo
C07D 233/70A61P 17/14A61P 35/00C07D 233/74C07D 471/10A61P 17/10C07D 235/02C07D 233/86A61P 13/08
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Claims

Abstract

The present invention relates to diarylhydantoin compounds, including diarylthiohydantoins, and methods for synthesizing them and using them in the treatment of hormone refractory prostate cancer.

Claims

exact text as granted — not AI-modified
1 .- 51 . (canceled) 
     
     
         52 . The compound of the formula 
       
         
           
           
               
               
           
         
       
     
     
         53 . A method of synthesizing a compound of formula 
       
         
           
           
               
               
           
         
         comprising
 mixing 4-isothiocyanato-2-trifluoromethylbenzonitrile, 1-(4-methylphenyl)aminocyclobutanenitrile, and DMF to form a first mixture; 
 allowing the first mixture to react; 
 isolating 4-(8-imino-6-thioxo-5-(4-methylphenyl)-5,7-diazaspiro[3.4]oct-7-yl)-2-trifluoromethylbenzonitrile from the first mixture; 
 mixing 4-(8-imino-6-thioxo-5-(4-methylphenyl)-5,7-diazaspiro[3.4]oct-7-yl)-2-trifluoromethylbenzonitrile, phenylthioisocyanate, and DMF to form a second mixture; 
 allowing the second mixture to react; and 
 isolating the compound.

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