Medical devices

Abstract

Described are medical devices including expandable tubular bodies configured to be implanted into a lumen, wherein the outer surface of the expandable tubular bodies are coupled to a polymer(s).

1 . A medical device, including:
 an outer surface coupled to a polymer prepared from the free radical polymerization of a first acrylate monomer and a second monomer including an amine, a carboxylic acid, or a hydroxyl functionality;   wherein the first monomer is an alkoxyalkyl (meth)acrylate, tetrahydrofurfuryl acrylate, or an alkoxyalkyl acrylate.   
     
     
         2 . The medical device of  claim 1 , including an expandable tubular body configured to be implanted into a blood vessel. 
     
     
         3 . The medical device of  claim 2 , wherein the expandable tubular body includes a metal. 
     
     
         4 . The medical device of  claim 3 , wherein the metal includes gold, silver, copper, steel, aluminum, titanium, cobalt, chromium, platinum, nickel, combinations thereof, or an alloy thereof. 
     
     
         5 . The medical device of  claim 4 , wherein the metal is a combination of nitinol and platinum-tungsten. 
     
     
         6 . The medical device of  claim 1 , wherein the polymer is covalently coupled to the outer surface. 
     
     
         7 . (canceled) 
     
     
         8 . The medical device of  claim 1 , wherein the alkoxyalkyl acrylate has the formula 
       
         
           
           
               
               
           
         
         wherein 
         R 1  is hydrogen, 
         R 2  is an alkylene group with 1 to 4 carbons, and 
         R 3  is an alkyl group with 1 to 4 carbons. 
       
     
     
         9 . The medical device of  claim 3 , wherein the metal includes nitinol (nickel-titanium), cobalt-nickel, cobalt-chromium, platinum-tungsten, or a combination thereof. 
     
     
         10 . (canceled) 
     
     
         11 . The medical device of  claim 1 ,
 wherein the outer surface is a silanized outer surface.   
     
     
         12 . The medical device of  claim 1 , wherein the outer surface is a hydroxylated outer surface. 
     
     
         13 . (canceled) 
     
     
         14 . The medical device of  claim 11 , wherein the outer surface is silanized to form the silanized outer surface through reaction with a silane selected from: 
       
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         or a combination thereof,
 wherein n is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15. 
 
       
     
     
         15 . The medical device of  claim 14 , wherein n is 8-12. 
     
     
         16 - 18 . (canceled) 
     
     
         19 . The medical device of  claim 11 , wherein the first monomer is alkoxyalkyl (meth)acrylate or tetrahydrofurfuryl acrylate. 
     
     
         20 . The medical device of  claim 11 , wherein the second monomer is acrylic acid, methacrylic acid, hydroxyethyl methacrylate, hydroxyethyl acrylate, hydroxypropyl acrylate, hydroxybutyl acrylate, aminoethyl methacrylate, aminopropyl methacrylamide, a combination thereof. 
     
     
         21 . The medical device of  claim 1 , wherein
 the outer surface is a silanized to form a silanized outer surface through reaction with a silane, wherein the silane includes a reactive group selected from an acrylate, methacrylate, aldehyde, epoxy, ester, or a combination thereof, and   the first monomer is alkoxyalkyl (meth)acrylate, tetrahydrofurfuryl acrylate, or   
       
         
           
           
               
               
           
         
         wherein 
         R 1  is hydrogen, 
         R 2  is an alkylene group with 1 to 4 carbons, and 
         R 3  is an alkyl group with 1 to 4 carbons. 
       
     
     
         22 . The medical device of  claim 21 , wherein the outer surface is a hydroxylated outer surface prior to being silanized. 
     
     
         23 . The medical device of  claim 21 , wherein the silane is selected from: 
       
         
           
           
               
               
           
         
         or a combination thereof. 
       
     
     
         24 . The medical device of  claim 21 , wherein the first monomer is tetrahydrofurfuryl acrylate. 
     
     
         25 . The medical device of  claim 21 , wherein the second monomer is acrylic acid, methacrylic acid, hydroxyethyl methacrylate, hydroxyethyl acrylate, hydroxypropyl acrylate, hydroxybutyl acrylate, aminoethyl methacrylate, aminopropyl methacrylamide, or a combination thereof. 
     
     
         26 . The medical device of  claim 21 , wherein the silane includes an epoxy reactive group. 
     
     
         27 . The medical device of  claim 21 , wherein the first monomer is alkoxyalkyl (meth)acrylate. 
     
     
         28 . The medical device of  claim 21 , wherein the silane is selected from: 
       
         
           
           
               
               
           
         
         or a combination thereof. 
       
     
     
         29 . The medical device of  claim 21 , wherein the second monomer is hydroxybutyl acrylate, aminopropyl methacrylamide, or a combination thereof. 
     
     
         30 . The medical device of  claim 21 , wherein the first monomer is methoxyethyl acrylate. 
     
     
         31 . The medical device of  claim 11 , wherein the outer surface is silanized to form the silanized outer surface through reaction with a silane, wherein the silane includes a reactive group selected from an acrylate, methacrylate, aldehyde, epoxy, ester, halogen, or combination thereof.