Novel compositions and methods for the treatment of immune related diseases

Abstract

The present invention relates to compositions and methods of using those compositions for the diagnosis and treatment of immune related diseases.

1 . An isolated polypeptide comprising an amino acid sequence comprising one or more of the following amino acids: an alanine at an amino acid position corresponding to amino acid position 67 of human TIGIT, a glycine at an amino acid position corresponding to amino acid position 74 of human TIGIT, a proline at an amino acid position corresponding to amino acid position 114 of human TIGIT, and a glycine at an amino acid position corresponding to amino acid position 116 of human TIGIT. 
     
     
         2 - 4 . (canceled) 
     
     
         5 . A method of determining whether a test polypeptide is a member of the TLP family of polypeptides comprising aligning the amino acid sequence of the test polypeptide with an amino acid sequence of one or more members of the TLP family of polypeptides and assessing the presence or absence in the test polypeptide amino acid sequence of any of the amino acids as set forth in  claim 1 . 
     
     
         6 . A method for identifying one or more members of the TLP protein family by identifying proteins in one or more sequence databases whose amino acid sequences comprise at least one of the amino acids as set forth in  claim 1 . 
     
     
         7 . An isolated agent that specifically interacts with one or more conserved or substantially conserved regions of TLP family members. 
     
     
         8 - 14 . (canceled) 
     
     
         15 . An anti-TIGIT antibody or a fragment thereof comprising at least one HVR comprising an amino acid sequence selected from the amino acid sequences set forth in SEQ ID NOs: 23-28 or SEQ ID NOs: 31-36. 
     
     
         16 - 38 . (canceled)