Expandable device for tissue collection from an aerodigestive body lumen

Abstract

A device for obtaining tissue from the aerodigestive tract is provided. The device may have internal and external folds and a tissue collection surface for collecting a tissue sample from a body lumen, such as the nose or throat. The present invention is also directed to methods of collecting a tissue sample using the devices, described herein.

1 . A method of collecting tissue from an individual, comprising:
 (a) advancing a deflated expandable device, wherein the expandable device comprises an outer surface sized to fit within a body lumen of an aerodigestive tract of a human, one or more regions of the outer surface comprising a tissue collection surface, wherein when the expandable device is deflated the outer surface has internal and external folds, wherein the tissue collection surface is present on one or more of the internal folds and is not present on the external folds, and wherein the tissue collection surface is an abrasive surface comprised of a coating of biocompatible plastic particulate comprising a granular size of about 5 to about 500 microns, to a collection site within a body lumen of an individual;   (b) expanding the expandable device at the collection site to unfurl at least some of the folds so that the tissue collection surface contacts tissue of the body lumen;   (c) collecting tissue on the tissue collection surface of the expandable device;   (d) contracting the expandable device; and   (e) removing the contracted expandable device from the individual.   
     
     
         2 - 18 . (canceled) 
     
     
         19 . An expandable device, comprising an outer surface sized to fit within a body lumen of an aerodigestive tract of a human, one or more regions of the outer surface having a tissue collection surface, wherein when the expandable device is deflated the outer surface has internal folds and external folds, wherein the tissue collection surface is present on one or more internal folds of the outer surface and is not present on one or more external folds, and wherein the tissue collection surface is an abrasive surface comprised of a coating of biocompatible plastic particulate comprising a granular size of about 5 to about 500 microns. 
     
     
         20 . The expandable device of  claim 19 , wherein the device is a balloon. 
     
     
         21 . The expandable device of  claim 20 , wherein the balloon is made of latex, silicone elastomer, butadiene/acrylonitride copolymers, copolyesters, ethylene vinylacetate (EVB) polymers, ethylene/acrylic copolymers, ethylene/propylene copolymers, polyalkylacrylate polymers, polybutadiene, polybutylene, polyethylene, polyisobutylene, polyisoprene, polyurethane, styrenebutadiene copolymers, and styrene-ethylene/butylene-styrene, polyesters, polyolefins, polyamides, polyvinyl chloride, or a combination thereof. 
     
     
         22 . The expandable device of  claim 20 , wherein the balloon has one or more inflatable compartments. 
     
     
         23 . The expandable device of  claim 20 , wherein the balloon has a shape selected from the group consisting of round, conical, oblong, and tissue specific. 
     
     
         24 . The expandable device of  claim 23 , wherein the tissue specific shape is a shape that is an approximate mirror image of a body lumen. 
     
     
         25 - 36 . (canceled) 
     
     
         37 . A balloon cytology device, comprising:
 a balloon having an outer surface sized to fit within an esophagus, one or more regions of the outer surface having a tissue collection surface; and   a support member having a proximal end region and a distal end region, wherein the support member is connected to the balloon at the distal end region and wherein the minimal length of the support member between the proximal end region and the distal end region is 10 cm, wherein the support member includes a hollow compartment for transferring a gas or liquid to balloon to inflate the balloon.   
     
     
         38 . The balloon cytology device of  claim 37 , wherein the balloon cytology device is attached to a tube or channel. 
     
     
         39 . The balloon cytology device of  claim 37 , wherein the balloon cytology device is coated with an agent. 
     
     
         40 . The balloon cytology device of  claim 39 , wherein the agent is coated on the internal folds of the expandable device. 
     
     
         41 . The balloon cytology device of  claim 39 , wherein the agent is a therapeutic agent, diagnostic agent, or imaging agent. 
     
     
         42 - 51 . (canceled)